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Download a copy of the latest published papers from NRI scientists:

Craciunescu, C.N., Johnson, A.R., Zeisel, S.H. (2010) Dietary choline reverses some, but all effects of folate deficiency on neurogenesis and apoptosis in the fetal mouse brain. The Journal of Nutrition. doi: jn.110.122044. (PDF)

Craciunescu, Corneliu N., Mehedint, Mihai G., and Zeisel, Steven H. (2010) Maternal dietary choline deficiency alters angiogenesis in fetal mouse hippocampus. Proceedings of the National Academy of Sciences PNAS 2010 : 0914328107v1-12839 (PDF)

Craig, S.S., Craig, Stuart, AS, Ganio, M.S., Maresh, C.M., Greg, H., da Costa, K-A, Zeisel, S.H., (2010) The betaine content of sweat from adolescent females. Journal of the International Society of Sports Nutrition, 7:3. (PDF)

Johnson, A.R., Craciunescu, C.N., Guo, Z., Teng, Y-W., Thresher, R.J., Blusztajn, J.K., Zeisel, S.H. (2010) Deletion of murine choline dehydrogenase results in diminished sperm motility. FASEB. doi: fj.09-153718. (PDF)

Lee, J.E., Giovannucci, E., Fuchs, C.S., Willett, W.C., Zeisel, S.H., Cho, E., (2010) Choline intake and the risk of colorectal cancer in men. Cancer Epidemiology, Biomarkers and Prevention. 19(3): 884 - 887. (PDF)

Sha, W., da Costa, K-A., Fischer, L.M., Milburn, M.V., Lawton, K.A., Berger, A., Jia, W., Zeisel, S.H. (2010) Metabolomic profiling can predict which humans will develop liver dysfunction when deprived of dietary choline. FASEB. Online fj.09-154054. (PDF)

Bidulescu, A., Chambless, L.E., Siga-Riz, A.M., Zeisel, S.H., and Heiss, G. (2009) Repeatability and measurement error in the assessment of choline and betaine dietary intake: the Atherosclerosis Risk in Communities (AIRC) Study. Nutrition Journal doi: 10.1186/1475-2891-8-14. PMCID: PMC2654540. (PDF)

daCosta, K., Rai, K.S.., Craciunescu, C.N., Parikh, K., Mehedint, M.G., Sanders, L.M., Pottinger, A.M., Zeisel, S.H. (2009) Dietary docosahexaenoic acid supplementation modulates hippocampal development in the Pemt mouse. Journal of Biological Chemistry. 285, 1008-1015. PMCID: PMC2801227. (PDF)

Mehedint, M.G., Niculescu, M.D., Craciunescu, C.N., Zeisel, S.H. (2009) Choline deficiency alters global histone methylation and epigenetic marking at the Re1 site of the calbindin 1 gene. FASEB Journal. 24(1): 184-195. PMCID: PMC2797040. (PDF)

Rosales, F.J., Reznick, S., Zeisel, S.H. (2009) Understanding the role of nutrition in the brain & behavioral development of toddlers and preschool children: identifying and overcoming methodological barriers. Nutritional Neuroscience 12(5), 190 - 202. (PDF)

Xu, X., Gammon, M.D., Zeisel, S.H., Bradshaw, P.T., Wetmur, J. G., Teitelbaum, S.L., Neugut, A.I., Santella, R.M., Chen, J. (2009) High intakes of choline and betaine reduce breast cancer mortality in a population-based study. FASEB Journal 23: 4022-8. PMCID: PMC2775010.  (PDF)

Zeisel, S.H. (2009) Importance of methyl donors during reproduction. American Journal of Clinical Nutrition 89(suppl.):673S-7S. PMCID: PMC2628952. (PDF)

Zeisel, S.H. (2009) Is maternal diet supplementation beneficial? Optimal Development of baby depends on mother’s diet. American Journal of Clinical Nutrition 89(suppl.):685S-7S. PMCID: PMC2647763. (PDF)

Zeisel, S.H. (2009) Epigenetic mechanisms for nutrition determinants of later health outcome. American Journal of Clinical Nutrition 89: 1488S-1493S. (PDF)

Zeisel, S.H. (2009) Choline: Clinical nutrigenomics approaches for identification of functions and dietary requirements. World Review of Nutrition and Dietetics, edited by A.P. Simopoulos, Washington, DC. 101: 73 - 83. (PDF)

Zeisel, S.H. (2009) Pregnancy Health. The Dole Nutrition Handbook, jointly edited by Rodale, the Dole Nutrition Institute, Jennifer Grossman and Nicholas Gillitt, New York, NY,  pp 173 – 183. (PDF)

Zeisel, S.H., daCosta, K. (2009) Choline: an essential nutrient for public health Nutrition Reviews 67(11): 615-623. PMCID: PMC2782876. (PDF)

Bidulescu, A.,Chambless, L.E., Seiga-Riz, A.M., Zeisel, S.H., Heiss, G. (2007) Usual choline and betaine dietary intake and incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) Study. BMC Cardiovascular Disorders DOI:10.1186/1471-2261-7-20. (PDF)

Fischer, L., da Costa, K., Kwock, L., Stewart, P., Lu, T., Stabler, S., Allen, R., Zeisel, S.H. (2007) Sex and menopausal status influence human dietary requirements for the nutrient choline. American Journal of Clinical Nutrition 85:1275-1285. (PDF)

Niculescu, M., Wu, R., Guo, Z.,da Costa, K-A., Zeisel, S.H. (2007) Diethanolamine alters proliferation and choline metabolism in mouse neural procursor cells. Toxicology Sciences 96(2): 321-326. (PDF)

Niculescu, M.,da Costa, K-A., Fischer, L., Zeisel, S.H. (2007) Lymphocyte gene expression in subjects fed low-choline diet differs between those who develop organ dysfunction and those who do not. American Journal of Clinical Nutrition 86: 230-239. (PDF)

Resseguie, M., Song, J., Niculescu, M., da Costa, K-A., Randall, T., Zeisel, S.H (2007) Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes. FASEB Journal DOI: 10.1096/fj.07-8227com. (PDF)

Steck, S., Gammon, M., Hebert, J., Wall, D., Zeisel, S.H. (2007) GSTM1, GSTT1, GSTP1, GSTA1 polymorphisms and urinary isothiocyanate metabolites following broccoli consumption in humans. Journal of Nutrition 137: 904-909. (PDF)

Zeisel, S.H (2007) Gene response elements, genetic polymorphisms and epigenetics influence the human dietary requirement for choline. IUBMB Life 59(6): 380-387. (PDF)

Zeisel, S.H. (2007) Nutrigenomics and metabolomics will change clinical nutrition and public health practice: insights from studies on dietary requirements of choline. American Journal of Clinical Nutrition 86: 542-548. (PDF)

da Costa, K. A., Kozyrez, O., Song, J., Galanko, J., Fischer, L., Zeisel, S.H. (2006) Common genetic polymorphisms affect the human requirement for the nutrient choline. FASEB Journal 20: 1336-1344. (PDF)

Niculescu, M., Craciunescu, C., Zeisel, S.H. (2006) Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains. FASEB Journal 20:43-49 (PDF)

Niculescu, M., Pop, E., Fischer, L., Zeisel, S.H. (2006) Dietary isoflavones differentially induce gene expression changes in lymphocytes from postmenopausal women who form equol as compared to those who do not. Journal of Nutritional Biochemistry DOI: 10.1016/j.jnutbio2006.06.002. (PDF)

Zeisel, S.H. (2006) The fetal origins of memory: the role of dietary choline in optimal brain development. The Journal of Pediatrics DOI: 10.1016/j.jpeds.2006.06.065 (PDF)

Kohlmeier, M., da Costa, K-A., Fischer, L., Zeisel, S.H. (2005) Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans. Proceedings of the National Academy of Sciences USA 44:16025-16030. (PDF)