The NRI's Research Goals

We focus on using cutting edge genomic and metabolomic biotechnology to develop innovative approaches to understanding the role of diet and activity in normal brain development, the prevention of cancer, and the prevention and treatment of obesity. This Institute will study individual metabolic variations to develop nutrition solutions that target individual susceptibilities and differences. Until now, nutritionists have had to rely on generic advice, but new technology increasingly makes it possible to understand metabolism at the level of the individual.

We:

1. Use genomic, proteomic and metabolomic methods to characterize humans in a manner not previously possible -- by identifying characteristics that predispose individuals to increased requirements for specific nutrients that are known to be associated with brain development and function, protection against cancer, and maintenance of normal body weight;
2. Conduct focused research in model systems to understand the potential mechanisms and significance of these individual differences in metabolism; and
3. Use this new understanding of human metabolic individuality to develop highly targeted solutions that will include clinical and community-based interventions with the goal of optimizing brain development and function, as well as preventing cancer, obesity, and the many sequelae of obesity (e.g., diabetes).