Using a mouse model, this study examined the impact of lack of betaine homocysteine S-methyltransferase (BHMT) on neurological function. Bhmt-/- mice maintained on a control diet had elevated concentrations of homocysteine, reduced total brain magnetic resonance imaging (MRI) volume, as well as impaired reference and short-term memories. The results of this study indicate that the absence of BHMT may play a role in neurological function.
Keywords: IRM; MRI; Morris water maze; Y-maze; betaine homocysteine S-methyltransferase; bétaïne homocystéine S-méthyltransférase; homocysteine; homocystéine; labyrinthe aquatique de Morris; labyrinthe en Y; memory; mémoire.