Environment and Nutrition
Beginning at conception, environmental factors in health can accumulate over a lifetime and be from sources as broad as geographic location and economic status to specific external sources including physical activity, occupation, risky behaviors and diet. But some of these factors, especially in terms of diet are highly modifiable.
Important research is now being conducted on this concept of the “exposome,” as an environmental complement to the human genome. NRI researchers are learning how diet and other environmental exposures interact with disease and affect responses to treatment.
Publications
Environment and Nutrition Publications
2020
Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity. Zeisel S
Perspective: Dietary Biomarkers of Intake and Exposure-Exploration with Omics Approaches. Zeisel S
2019
Obesity and Cancer Metabolism: A Perspective on Interacting Tumor-Intrinsic and Extrinsic Factors. Hursting S
When less may be more: calorie restriction and response to cancer therapy. Hursting S
Energy balance and obesity: what are the main drivers? Hursting S
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Early-Life Predictors of Fetal Alcohol Spectrum Disorders. May P
Alcohol’s Dysregulation of Maternal-Fetal IL-6 and p-STAT3 Is a Function of Maternal Iron Status. Smith S
2018
Energy balance and gastrointestinal cancer: risk, interventions, outcomes and mechanisms. Hursting S
Research Strategies for Nutritional and Physical Activity Epidemiology and Cancer Prevention. Hursting S
2017
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Contribution of Dietary Supplements to Nutritional Adequacy in Various Adult Age Groups. Zeisel S
2016
CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress. Krupenko N
Abnormal Eating Behaviors Are Common in Children with Fetal Alcohol Spectrum Disorder. Smith S
Impact of a western diet on the ovarian and serum metabolome. Sumner S
Metabolomics enables precision medicine: “A White Paper, Community Perspective”. Sumner S
Related News
ALDH1L1 inhibits cell motility via dephosphorylation of cofilin by PP1 and PP2A
ALDH1L1 inhibits cell motility via dephosphorylation of cofilin by PP1 and PP2A.
Oleinik NV, Krupenko NI, Krupenko SA.
Oncogene. 2010 Nov 25;29(47):6233-44. doi: 10.1038/onc.2010.356. Epub 2010 Aug 23.
PMID: 20729910
Phylogeny and evolution of aldehyde dehydrogenase-homologous folate enzymes
Phylogeny and evolution of aldehyde dehydrogenase-homologous folate enzymes.
Strickland KC, Holmes RS, Oleinik NV, Krupenko NI, Krupenko SA.
Chem Biol Interact. 2011 May 30;191(1-3):122-8. doi: 10.1016/j.cbi.2010.12.025. Epub 2011 Jan 6.
PMID: 21215736
ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase
ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase.
Krupenko NI, Dubard ME, Strickland KC, Moxley KM, Oleinik NV, Krupenko SA.
J Biol Chem. 2010 Jul 23;285(30):23056-63. doi: 10.1074/jbc.M110.128843. Epub 2010 May 24.
PMID: 20498374
Acyl carrier protein-specific 4′-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase
Acyl carrier protein-specific 4′-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase.
Strickland KC, Hoeferlin LA, Oleinik NV, Krupenko NI, Krupenko SA.
J Biol Chem. 2010 Jan 15;285(3):1627-33. doi: 10.1074/jbc.M109.080556. Epub 2009 Nov 20.
PMID: 19933275
Folate stress induces apoptosis via p53-dependent de novo ceramide synthesis and up-regulation of ceramide synthase 6
Folate stress induces apoptosis via p53-dependent de novo ceramide synthesis and up-regulation of ceramide synthase 6.
Hoeferlin LA, Fekry B, Ogretmen B, Krupenko SA, Krupenko NI.
J Biol Chem. 2013 May 3;288(18):12880-90. doi: 10.1074/jbc.M113.461798. Epub 2013 Mar 21.
PMID: 23519469
January 2015
Clinical Studies at the Nutrition Research Institute The Nutrition Research Institute is committed to conducting innovative, basic and translational science to support the understanding of individualized nutrition. These advances in science promote the prevention and...