Environment and Nutrition
Beginning at conception, environmental factors in health can accumulate over a lifetime and be from sources as broad as geographic location and economic status to specific external sources including physical activity, occupation, risky behaviors and diet. But some of these factors, especially in terms of diet are highly modifiable.
Important research is now being conducted on this concept of the “exposome,” as an environmental complement to the human genome. NRI researchers are learning how diet and other environmental exposures interact with disease and affect responses to treatment.
Publications
Environment and Nutrition Publications
2020
Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity. Zeisel S
Perspective: Dietary Biomarkers of Intake and Exposure-Exploration with Omics Approaches. Zeisel S
2019
Obesity and Cancer Metabolism: A Perspective on Interacting Tumor-Intrinsic and Extrinsic Factors. Hursting S
When less may be more: calorie restriction and response to cancer therapy. Hursting S
Energy balance and obesity: what are the main drivers? Hursting S
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Early-Life Predictors of Fetal Alcohol Spectrum Disorders. May P
Alcohol’s Dysregulation of Maternal-Fetal IL-6 and p-STAT3 Is a Function of Maternal Iron Status. Smith S
2018
Energy balance and gastrointestinal cancer: risk, interventions, outcomes and mechanisms. Hursting S
Research Strategies for Nutritional and Physical Activity Epidemiology and Cancer Prevention. Hursting S
2017
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Contribution of Dietary Supplements to Nutritional Adequacy in Various Adult Age Groups. Zeisel S
2016
CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress. Krupenko N
Abnormal Eating Behaviors Are Common in Children with Fetal Alcohol Spectrum Disorder. Smith S
Impact of a western diet on the ovarian and serum metabolome. Sumner S
Metabolomics enables precision medicine: “A White Paper, Community Perspective”. Sumner S
Related News
Healthy Brain Function Tied to Nutrition
November 24, 2015 • The research in Dr. Carol L. Cheatham’s Nutrition and Cognition lab focuses on effects of nutrition on brain development and function throughout the lifespan. In her work, she is exploring the importance of certain nutrients and foods to the development, maintenance, and lifelong integrity of the hippocampus and frontal brain areas. Nutrition is integral to fetal and infant brain development, which sets the stage for lifelong learning. At the other end of the spectrum, it is beginning to be evident that nutrition is also important in senescence in that certain nutrients coupled with other healthy lifestyle choices can slow the progression of age-related cognitive decline. Dr. Cheatham has active studies in four age groups; some of that work is summarized here.
NRI Researcher Receives Award to Further Work on Obesity and Cancer
December 1, 2015 • University of North Carolina (UNC) at Chapel Hill professor Stephen Hursting has received a prestigious National Cancer Institute (NCI) Outstanding Investigator Award (OIA), which provides stable funding for cancer research with breakthrough potential. Dr. Hursting, a professor in UNC’s Department of Nutrition, Nutrition Research Institute and Lineberger Comprehensive Cancer Center, is one of 43 researchers nationwide to receive an OIA. The grant will provide Hursting with $5.34 million over a seven-year period to further his research on the mechanistic links between obesity and cancer.
Dr. Hursting Awarded Grant from Breast Cancer Research Foundation
October 28, 2015 • The Breast Cancer Research Foundation seeks “to prevent and cure breast cancer by advancing the world’s most promising research.”Since 1993 BCRF-supported investigators have been deeply involved in every major advance in breast cancer prevention, diagnosis and treatment. In 2015-2016, BCRF is awarding $48.5 million in grants to more than 240 scientists to advance this work. Among those recipients is Stephen Hursting, Ph.D., M.P.H., Professor of Nutrition at the UNC Nutrition Research Institute.
Is Life Expectancy a Good Measure of Health?
October 27, 2015 • A recent, global study published in The Lancet (2015; 386, p.743-800) clearly emphasizes the importance of the latter referring to our quality of life. According to the Global Burden of Disease (GBD) study, worldwide life expectancy at birth rose by 6.2 years between 1990 and 2013. However, these additional years come at a price as healthy life expectancy at birth increased by only 5.4 years over the same 13 year time span.
Arugula, Mozzarella and Black Grapes
October 27, 2015 • Arugula, Mozzarella and Black Grapes recipe designed by Chef Mark Allison, Dole Food Company.
Researchers Say Absolutely No Drinking While Pregnant
October 21, 2015 • Fetal Alcohol Syndrome (FAS) in the United States has long been estimated at no more than three children per 1,000. A new study published in the journal of Drug and Alcohol Dependence reports that the prevalence of fetal alcohol syndrome (FAS) is between 3 and 8 per 1,000 and when combined with partial FAS (PFAS) the prevalence of both actually ranges between 11 to 25 children per 1,000.
Lead researcher Philip May, Ph.D., research professor with the UNC Nutrition Research Institute (NRI) at the NC Research Campus in Kannapolis, NC, emphasized that the study “Prevalence and characteristics of fetal alcohol syndrome and partial fetal syndrome in Rocky Mountain Region City” is only the second population-based study completed in the United States that aimed to establish more accurate rates of FAS and PFAS.