Environment and Nutrition
Beginning at conception, environmental factors in health can accumulate over a lifetime and be from sources as broad as geographic location and economic status to specific external sources including physical activity, occupation, risky behaviors and diet. But some of these factors, especially in terms of diet are highly modifiable.
Important research is now being conducted on this concept of the “exposome,” as an environmental complement to the human genome. NRI researchers are learning how diet and other environmental exposures interact with disease and affect responses to treatment.
Publications
Environment and Nutrition Publications
2020
Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity. Zeisel S
Perspective: Dietary Biomarkers of Intake and Exposure-Exploration with Omics Approaches. Zeisel S
2019
Obesity and Cancer Metabolism: A Perspective on Interacting Tumor-Intrinsic and Extrinsic Factors. Hursting S
When less may be more: calorie restriction and response to cancer therapy. Hursting S
Energy balance and obesity: what are the main drivers? Hursting S
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Early-Life Predictors of Fetal Alcohol Spectrum Disorders. May P
Alcohol’s Dysregulation of Maternal-Fetal IL-6 and p-STAT3 Is a Function of Maternal Iron Status. Smith S
2018
Energy balance and gastrointestinal cancer: risk, interventions, outcomes and mechanisms. Hursting S
Research Strategies for Nutritional and Physical Activity Epidemiology and Cancer Prevention. Hursting S
2017
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Contribution of Dietary Supplements to Nutritional Adequacy in Various Adult Age Groups. Zeisel S
2016
CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress. Krupenko N
Abnormal Eating Behaviors Are Common in Children with Fetal Alcohol Spectrum Disorder. Smith S
Impact of a western diet on the ovarian and serum metabolome. Sumner S
Metabolomics enables precision medicine: “A White Paper, Community Perspective”. Sumner S
Related News
October 2015
October 8, 2015 • In this month’s soundbite you will learn how “antioxidants” affect the body’s immune system. Sign up for this month’s AFL presentation by Dr. Surzenko. Also it’s not too early to buy a Christmas present. Consider giving a memorial brick in the NRI’s plaza.
Our Built-In “Antioxidant” System
October 1, 2015 • Antioxidants have been in the popular press for more than 20 years and, while many people may not understand what exactly antioxidants do, they have the right idea that consuming foods known to contain high levels of the compounds is better than not consuming them. In its simplest form, an antioxidant is a compound that can be consumed or that the body makes to defend against damaging effects of free radicals, highly reactive molecules that can damage cells and tissues. We are exposed to free radicals through everyday living.
Sunset Slaw
September 24, 2015 • Sunset Slaw recipe designed by Chef Mark Allison, Dole Food Company.
Impact Report 2014-15
Steve H. Zeisel, institute director, addressing faculty and staff in his lab. In the past year scientists at the Nutrition Research Institute have made significant advances in our understanding of the roles genetics and nutrition play in determining our individual susceptibility and resistance to disease. This is our bold mission: to discover the mechanisms by which diet can prevent or lessen the negative effects of chronic diseases and aging, and improve human development, even prior to concep
New Study Shows How Phytochemicals Build Natural Defenses Against Free Radicals
September 21, 2015 • A new study from scientists at the NC Research Campus (NCRC) in Kannapolis, NC, found that certain phytochemicals build natural, cellular defenses against damaging free radicals and reactive oxygen species dispelling other popular theories of how some antioxidants work.
Researcher Returns to Familiar Ground for Groundbreaking Work
September 17, 2015 • The following has been reprinted from the Charlotte Observer.
Growing up in Kannapolis, Summer Goodson knew that the mammoth Cannon Mills textile complex was the lifeblood of the community.
Members of her family worked in the plant for 70 years before Pillowtex shuttered the facility in 2003. Little did Goodson know that she would carry on her family’s legacy by one day working in some of the same buildings. But instead of spinning cotton into fiber, Goodson is turning research into medical advancements aimed at helping treat male infertility.