Environment and Nutrition
Beginning at conception, environmental factors in health can accumulate over a lifetime and be from sources as broad as geographic location and economic status to specific external sources including physical activity, occupation, risky behaviors and diet. But some of these factors, especially in terms of diet are highly modifiable.
Important research is now being conducted on this concept of the “exposome,” as an environmental complement to the human genome. NRI researchers are learning how diet and other environmental exposures interact with disease and affect responses to treatment.
Publications
Environment and Nutrition Publications
2020
Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity. Zeisel S
Perspective: Dietary Biomarkers of Intake and Exposure-Exploration with Omics Approaches. Zeisel S
2019
Obesity and Cancer Metabolism: A Perspective on Interacting Tumor-Intrinsic and Extrinsic Factors. Hursting S
When less may be more: calorie restriction and response to cancer therapy. Hursting S
Energy balance and obesity: what are the main drivers? Hursting S
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Early-Life Predictors of Fetal Alcohol Spectrum Disorders. May P
Alcohol’s Dysregulation of Maternal-Fetal IL-6 and p-STAT3 Is a Function of Maternal Iron Status. Smith S
2018
Energy balance and gastrointestinal cancer: risk, interventions, outcomes and mechanisms. Hursting S
Research Strategies for Nutritional and Physical Activity Epidemiology and Cancer Prevention. Hursting S
2017
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Contribution of Dietary Supplements to Nutritional Adequacy in Various Adult Age Groups. Zeisel S
2016
CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress. Krupenko N
Abnormal Eating Behaviors Are Common in Children with Fetal Alcohol Spectrum Disorder. Smith S
Impact of a western diet on the ovarian and serum metabolome. Sumner S
Metabolomics enables precision medicine: “A White Paper, Community Perspective”. Sumner S
Related News
Vitamins and Healthy Diet: A Balancing Act
May 27, 2015 • A vitamin is an organic compound that cannot be made by the human body, but is a required nutrient vital for its various functions. Vitamins are needed in only limited amounts and thus are traditionally derived from our diet. And, yet, nearly half of the U.S. population takes multivitamin supplements—even in times of financial downturn. In 2010 the U.S. supplements industry reached $28 billion in annual sales. And, although no clear scientific need has been defined for vitamin supplementation, the most common reason for taking vitamins is a desire to “improve” or “maintain” overall health, according to a poll conducted by the National Institutes of Health in 2013.
ISNN congress to expand the evidence base for genome-directed personal nutrition
May 11, 2015 • The 9th Congress of the International Society of Nutrigenetics and Nutrigenomics (ISNN) presents “Expanding the Evidence Base for Genome-directed Personal Nutrition.”
Ammerman to co-lead UNC’s new campus theme – ‘Food for All’
May 4, 2015 • Members of the UNC-Chapel Hill community will come together at a common table when they examine food studies as UNC’s 2015-2017 university-wide academic theme.
“Food for All: Local and Global Perspectives,” which builds on UNC’s 2012-2015 “Water in Our World” focus on global water issues, will challenge all areas of the university to examine wide-ranging topics from food cultures and nutrition, to food security, world hunger, agricultural economics, resource management, sustainable development, climate change and international trade.
May 2015
May 6, 2015 • May 2015’s SoundBites features: Renowned Nutrition Scientist Speaks on Longevity; Nutrient Bar Results in Broadscale Health Improvements After Only Two Months; Eat More Produce, Reduce Cancer; and the Lettuce Eat Café
Nutrient Bar Results in Broadscale Health Improvements After Only Two Months
May 1, 2015 • A fruit-based micronutrient and fiber-dense supplement bar (the “CHORI-bar”), conceived by Drs. Bruce Ames and Mark K. Shigenaga at Children’s Hospital Oakland Research Institute (CHORI), was shown in clinical trials to improve metabolism in overweight/obese (OW/OB) otherwise healthy adults in ways that are consistent with reduced risk of type 2 diabetes and cardiovascular disease. Consumption of the bar for two months also reduced chronic inflammation, and initiated a reduction in weight and waist circumference. Decreased inflammation and improved weight and weight distribution can lower the risk of many chronic diseases.
UNC-Chapel Hill explores “Food for All” with 2015-2017 campus theme
April 30, 2015 • The University of North Carolina at Chapel Hill will come together at a common table when it examines food and food studies as its 2015-2017 university-wide academic theme. “Food for All: Local and Global Perspectives,” which builds on Carolina’s 2012-2015 “Water in Our World” focus on global water issues, will challenge all areas of the University to examine wide-ranging topics from food cultures and nutrition, to food security, world hunger, agricultural economics, resource management, sustainable development, climate change and international trade.