Environment and Nutrition
Beginning at conception, environmental factors in health can accumulate over a lifetime and be from sources as broad as geographic location and economic status to specific external sources including physical activity, occupation, risky behaviors and diet. But some of these factors, especially in terms of diet are highly modifiable.
Important research is now being conducted on this concept of the “exposome,” as an environmental complement to the human genome. NRI researchers are learning how diet and other environmental exposures interact with disease and affect responses to treatment.
Publications
Environment and Nutrition Publications
2020
Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity. Zeisel S
Perspective: Dietary Biomarkers of Intake and Exposure-Exploration with Omics Approaches. Zeisel S
2019
Obesity and Cancer Metabolism: A Perspective on Interacting Tumor-Intrinsic and Extrinsic Factors. Hursting S
When less may be more: calorie restriction and response to cancer therapy. Hursting S
Energy balance and obesity: what are the main drivers? Hursting S
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Early-Life Predictors of Fetal Alcohol Spectrum Disorders. May P
Alcohol’s Dysregulation of Maternal-Fetal IL-6 and p-STAT3 Is a Function of Maternal Iron Status. Smith S
2018
Energy balance and gastrointestinal cancer: risk, interventions, outcomes and mechanisms. Hursting S
Research Strategies for Nutritional and Physical Activity Epidemiology and Cancer Prevention. Hursting S
2017
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Contribution of Dietary Supplements to Nutritional Adequacy in Various Adult Age Groups. Zeisel S
2016
CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress. Krupenko N
Abnormal Eating Behaviors Are Common in Children with Fetal Alcohol Spectrum Disorder. Smith S
Impact of a western diet on the ovarian and serum metabolome. Sumner S
Metabolomics enables precision medicine: “A White Paper, Community Perspective”. Sumner S
Related News
Carol L. Cheatham, Ph.D. presented with National TRIO Achiever’s Award
On September 9, at Council for Opportunity in Education’s 33rd Annual Conference Gala, Dr. Cheatham was bestowed the 2014 National TRIO Achiever’s Award. The National TRIO Achiever’s award was created as a tribute to the success and outstanding endeavors of TRIO students and the programs that supported them in their journey to accomplished careers.
Artificial Sweeteners: New Findings Suggest Negative Health Implications
As a registered dietitian, I am often asked: “What do you think about artificial sweeteners?” My answer is always the same: “Since they are artificial and not enough research has been conducted to know for certain if they can be harmful, I suggest using them in moderation, learning to drink beverages that are naturally sugar-free, or using regular sugar instead but in moderation.” New research published in the journal Nature indicates a negative impact of artificial sweeteners on the helpful bacteria that live in our intestines. The findings were intriguing and provide one important piece of the puzzle to help better understand the role of these food additives on health.
Zbtb16 has a role in brown adipocyte bioenergetics
Zbtb16 has a role in brown adipocyte bioenergetics.
Plaisier CL, Bennett BJ, He A, Guan B, Lusis AJ, Reue K, Vergnes L.
Nutr Diabetes. 2012 Sep 17;2:e46. doi: 10.1038/nutd.2012.21.
PMID: 23446662
Quantitative trait loci affecting atherosclerosis at the aortic root identified in an intercross between DBA2J and 129S6 apolipoprotein E-null mice
Quantitative trait loci affecting atherosclerosis at the aortic root identified in an intercross between DBA2J and 129S6 apolipoprotein E-null mice.
Kayashima Y, Tomita H, Zhilicheva S, Kim S, Kim HS, Bennett BJ, Maeda N.
PLoS One. 2014 Feb 20;9(2):e88274. doi: 10.1371/journal.pone.0088274. eCollection 2014.
PMID: 24586312
Comparative genome-wide association studies in mice and humans for trimethylamine N-oxide, a proatherogenic metabolite of choline and L-carnitine
Hartiala J, Bennett BJ, Tang WH, Wang Z, Stewart AF, Roberts R, McPherson R, Lusis AJ, Hazen SL, Allayee H; CARDIoGRAM Consortium.
Arterioscler Thromb Vasc Biol. 2014 Jun;34(6):1307-13. doi: 10.1161/ATVBAHA.114.303252. Epub 2014 Mar 27.
PMID: 24675659
Genetic regulation of mouse liver metabolite levels
Genetic regulation of mouse liver metabolite levels.
Ghazalpour A, Bennett BJ, Shih D, Che N, Orozco L, Pan C, Hagopian R, He A, Kayne P, Yang WP, Kirchgessner T, Lusis AJ.
Mol Syst Biol. 2014 May 23;10:730. doi: 10.15252/msb.20135004.
PMID: 24860088