Environment and Nutrition
Beginning at conception, environmental factors in health can accumulate over a lifetime and be from sources as broad as geographic location and economic status to specific external sources including physical activity, occupation, risky behaviors and diet. But some of these factors, especially in terms of diet are highly modifiable.
Important research is now being conducted on this concept of the “exposome,” as an environmental complement to the human genome. NRI researchers are learning how diet and other environmental exposures interact with disease and affect responses to treatment.
Publications
Environment and Nutrition Publications
2020
Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity. Zeisel S
Perspective: Dietary Biomarkers of Intake and Exposure-Exploration with Omics Approaches. Zeisel S
2019
Obesity and Cancer Metabolism: A Perspective on Interacting Tumor-Intrinsic and Extrinsic Factors. Hursting S
When less may be more: calorie restriction and response to cancer therapy. Hursting S
Energy balance and obesity: what are the main drivers? Hursting S
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Early-Life Predictors of Fetal Alcohol Spectrum Disorders. May P
Alcohol’s Dysregulation of Maternal-Fetal IL-6 and p-STAT3 Is a Function of Maternal Iron Status. Smith S
2018
Energy balance and gastrointestinal cancer: risk, interventions, outcomes and mechanisms. Hursting S
Research Strategies for Nutritional and Physical Activity Epidemiology and Cancer Prevention. Hursting S
2017
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Contribution of Dietary Supplements to Nutritional Adequacy in Various Adult Age Groups. Zeisel S
2016
CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress. Krupenko N
Abnormal Eating Behaviors Are Common in Children with Fetal Alcohol Spectrum Disorder. Smith S
Impact of a western diet on the ovarian and serum metabolome. Sumner S
Metabolomics enables precision medicine: “A White Paper, Community Perspective”. Sumner S
Related News
The Folic Acid Dilemma
April 1, 2015 • In 1996, the Food and Drug Administration (FDA) made it mandatory to add folic acid (FA) to grain products used to make cereal, bread, pasta and other foods. The ruling, which was intended to prevent neural tube defects (NTDs) – see Sidebar – has been very successful: The incidence of NTDs fell 36% over the following decade.
The FDA’s ruling was unique because the target population (women of child-bearing age) is much smaller than the population affected (anyone eating fortified foods), especially now that so many countries around the world add FA to wheat, corn, and rice. Luckily, studies around the globe prove that FA benefits the general population by lowering the incidence of heart disease, stroke, and even mood disorders…which is why FA is also present in multivitamin supplements.
Pinpointing Individual Susceptibility for Heart Disease
March 31, 2015 • The following has been reprinted from NC Research Campus, transforming-science.com
Eat a healthy and balanced diet. That is the first advice that people who need to reduce their risk for cardiovascular disease (CVD) receive. But what if some nutrients in “healthy” foods interact with an individual’s genetic make-up in a way that actually increases their risk for CVD.
That is the question that Brian Bennett, PhD, is trying to answer. Bennett is an assistant professor of genetics, nutrition and heart disease with the UNC Chapel Hill Nutrition Research Institute (NRI) at the NC Research Campus in Kannapolis. He is pushing the boundaries of nutrigenomics, which is the study of how genes and diet interact, to reveal new clues about individual susceptibility for atherosclerosis and other forms of CVD.
April 2015
April 22 • April 2015’s edition of SoundBites features: The Folic Acid Dilemma, Appetite for Life Lecture, Liver Cancer Report Reveals New Links, Training Your Doctor in Nutrition, and 2015 ISNN Congress.
2015 ISNN Congress
March 30, 2015 • The International Society of Nutrigenetics and Nutrigenomics (ISNN) will hold its 9th Congress May 17-19 on the campus of UNC Chapel Hill. This event convenes several hundred nutrition researchers, clinicians, dietitians and other healthcare providers who are leaders in the development and practice of advanced nutrition solutions. Keynote speakers are 2007 Nobel laureate Dr. Oliver Smithies (UNC Chapel Hill) and Dr. Bruce Ames (Children’s Hospital Oakland Research Institute and UC Berkeley), who will deliver an Appetite for Life lecture in Kannapolis May 20, 2015.
Local Research Institute Boosts Economy through Critical Nutrition Discoveries
March 17, 2015 • Eleven faculty research scientists at the UNC Nutrition Research Institute (NRI) in Kannapolis currently have externally funded grants to support their work exploring individualized nutrition. These awards are significant not only for providing the means by which the NRI can advance its scientific discoveries but also for their economic impact in the Charlotte region.
Research campus moving past slow start, looking to define future
March 8, 2015 • The following has been reprinted from The Salisbury Post, an article by Josh Bergeron.
The N.C. Research Campus still lags behind initial employment projections, but, as the nation and state recover from an economic recession, growth is beginning to pick up.
Following billionaire businessman David Murdock’s $15 million annual endowment last year, the research campus aims to expand and the David H. Murdock Research Institution is looking to refocus on its initial intent — becoming a world class research institution. The catchphrase being used to define the future of the facility is “putting the RI back in DHMRI.”