Environment and Nutrition
Beginning at conception, environmental factors in health can accumulate over a lifetime and be from sources as broad as geographic location and economic status to specific external sources including physical activity, occupation, risky behaviors and diet. But some of these factors, especially in terms of diet are highly modifiable.
Important research is now being conducted on this concept of the “exposome,” as an environmental complement to the human genome. NRI researchers are learning how diet and other environmental exposures interact with disease and affect responses to treatment.
Publications
Environment and Nutrition Publications
2020
Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity. Zeisel S
Perspective: Dietary Biomarkers of Intake and Exposure-Exploration with Omics Approaches. Zeisel S
2019
Obesity and Cancer Metabolism: A Perspective on Interacting Tumor-Intrinsic and Extrinsic Factors. Hursting S
When less may be more: calorie restriction and response to cancer therapy. Hursting S
Energy balance and obesity: what are the main drivers? Hursting S
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Early-Life Predictors of Fetal Alcohol Spectrum Disorders. May P
Alcohol’s Dysregulation of Maternal-Fetal IL-6 and p-STAT3 Is a Function of Maternal Iron Status. Smith S
2018
Energy balance and gastrointestinal cancer: risk, interventions, outcomes and mechanisms. Hursting S
Research Strategies for Nutritional and Physical Activity Epidemiology and Cancer Prevention. Hursting S
2017
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Contribution of Dietary Supplements to Nutritional Adequacy in Various Adult Age Groups. Zeisel S
2016
CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress. Krupenko N
Abnormal Eating Behaviors Are Common in Children with Fetal Alcohol Spectrum Disorder. Smith S
Impact of a western diet on the ovarian and serum metabolome. Sumner S
Metabolomics enables precision medicine: “A White Paper, Community Perspective”. Sumner S
Related News
Gut Microbes Can Determine Your Weight
From the desk of: Steve Zeisel, M.D., Ph.D. Gut microbes have been making a lot of news lately. As the name implies, these bacteria reside in the intestine and fulfill a variety of functions essential to our health, specifically ensuring that we digest foods properly....
Alcohol Use, Working Conditions, Job Benefits, and the Legacy of the "Dop" System
Gossage, JP, Snell, CL, Parry, CDH, Marais, AS, Barnard, R, Vries, M, Blankenship, J, Seedat, S, Hasken, JM, May, PA. Alcohol Use, Working Conditions, Job Benefits, and the Legacy of the “Dop” System. In. J. Environ. Res. Public Health 2014, 11, 7406-7424.
Callosal Thickness Reductions relate to Facial Dysmorphology in Fetal Alcohol Spectrum Disorders
Yang, Y, Phillips, OR, Kan, E, Sulik, KK, Mattson, SN, Riley, EP, Jones, KL, Adnams, CM, May, PA, O’Connor, MJ, Narr, KL, Sowell, ER. Callosal Thickness Reductions relate to Facial Dysmorphology in Fetal Alcohol Spectrum Disorders. Alcohol Clin Exp Res. 2012 May; 36(5): 798-806.
Case Management Reduces Drinking During Pregnancy among High Risk Women
May, PA, Marais, AS, Gossage, JP, Barnard, R, Joubert, B, Cloete, M,Hendricks, N, Roux, S, Blom, A, Steenekamp, J, Alexander, T, Andreas, R, Human, S, Snell, C, Seedat, S, Parry, CC, Kalberg WO, Buckey D, Blankenship, J. Case Management Reduces Drinking During Pregnancy among High Risk Women. Int J Alcohol Drug Res. 2013 May 1; 2(3): 61-70.
Executive Function Predicts Adaptive Behavior in Children with Histories of Heavy Prenatal Alcohol Exposure and Attention Deficit/Hyperactivity Disorder
Ware, AL, Crocker, N, O’Brien, JW, Deweese, BN, Roesch, SC, Coles, CD, Kable, JA, May, PA, Kalberg, WO, Sowell, ER, Jones, KL, Riley, EP, Mattson, SN. Executive Function Predicts Adaptive Behavior in Children with Histories of Heavy Prenatal Alcohol Exposure and Attention Deficit/Hyperactivity Disorder. Alcohol Clin Exp Res. 2012 August; 36(8): 1431-1441.
Further Development of a Neurobehavioral Profile of Fetal Alcohol Spectrum Disorders
Mattson, SN, Roesch, SC, Glass, L, Deweese, BN, Coles, CD, Kable, JA, May, PA, Kalberg, WO, Sowell, ER, Adnams, CM, Jones, KL, Riley, EP. Further Development of a Neurobehavioral Profile of Fetal Alcohol Spectrum Disorders. Alcohol Clin Exp Res. 2013 March; 37(3): 517-528.