Environment and Nutrition
Beginning at conception, environmental factors in health can accumulate over a lifetime and be from sources as broad as geographic location and economic status to specific external sources including physical activity, occupation, risky behaviors and diet. But some of these factors, especially in terms of diet are highly modifiable.
Important research is now being conducted on this concept of the “exposome,” as an environmental complement to the human genome. NRI researchers are learning how diet and other environmental exposures interact with disease and affect responses to treatment.
Publications
Environment and Nutrition Publications
2020
Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity. Zeisel S
Perspective: Dietary Biomarkers of Intake and Exposure-Exploration with Omics Approaches. Zeisel S
2019
Obesity and Cancer Metabolism: A Perspective on Interacting Tumor-Intrinsic and Extrinsic Factors. Hursting S
When less may be more: calorie restriction and response to cancer therapy. Hursting S
Energy balance and obesity: what are the main drivers? Hursting S
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Early-Life Predictors of Fetal Alcohol Spectrum Disorders. May P
Alcohol’s Dysregulation of Maternal-Fetal IL-6 and p-STAT3 Is a Function of Maternal Iron Status. Smith S
2018
Energy balance and gastrointestinal cancer: risk, interventions, outcomes and mechanisms. Hursting S
Research Strategies for Nutritional and Physical Activity Epidemiology and Cancer Prevention. Hursting S
2017
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Contribution of Dietary Supplements to Nutritional Adequacy in Various Adult Age Groups. Zeisel S
2016
CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress. Krupenko N
Abnormal Eating Behaviors Are Common in Children with Fetal Alcohol Spectrum Disorder. Smith S
Impact of a western diet on the ovarian and serum metabolome. Sumner S
Metabolomics enables precision medicine: “A White Paper, Community Perspective”. Sumner S
Related News
Maternal Factors Predicting Cognitive and Behavioral Characteristics of Children with Fetal Alcohol Spectrum Disorders
May, PA, Tabachnick, BG, Gossage, JP, Kalberg, WO, Marais, AS, Robinson, LK, Manning, MA, Blankenship, J, Buckley, D, Hoyme, HE, Adnams, CM. Maternal Factors Predicting Cognitive and Behavioral Characteristics of Children with Fetal Alcohol Spectrum Disorders. J Dev Behav Pediatr. 2013 June; 34 (5): 314-325.
Prenatal Alcohol Exposure, ADHD, and Sluggish Cognitive Tempo
Graham, DM, Crocker, N, Deweese, BN, Roesch, SC, Coles, CD, Kable, JA, May, PA, Kalberg, WO, Sowell, ER, Jones, KL, Riley, EP, Mattson, SN. Prenatal Alcohol Exposure, ADHD, and Sluggish Cognitive Tempo. Alcohol Clin Exp Res. 2013 January; 37 (Suppl 1): E338-E346.
The Effects of Prenatal Alcohol Exposure and Attention-Deficit/Hyperactivity Disorder on Psychopathology and Behavior
Ware, AL, O’Brien, J W, Crocker, N, Deweese, BN, Roesch, SC, Coles, CD, Kable, JA, May, PH, Kalber, WO, Soweel, ER, Jones, KL, Riley, EP, Mattson, SN. The Effects of Prenatal Alcohol Exposure and Attention-Deficit/Hyperactivity Disorder on Psychopathology and Behavior. Alchol Clin Exp Res. 2013 March; 37(3): 507-516. doi:10.1111/j.1530-02777.2012.01953x.
Approaching the Prevalence of the Full Spectrum of Fetal Alcohol Spectrum Disorders in a South African Population-Based Study
May, PA, Blankenship, J, Marais, A, Gossage, JP, Kalberg, WO, Barnard, R, Vries, M, Robinson, LK, Adnams, CM, Buckley, D, Manning, M, Jones, KL, Parry, C, Hoyme, HE, Seedat, S. Approaching the Prevalence of the Full Spectrum of Fetal Alcohol Spectrum Disorders in a South African Population-Based Study. Alcohol Clin Exp Res. 2013 May; 37(5): 8180830. doi:10.1111/acer.12033.
Regional Brain Volume Reductions Relate to Facial Dysmorphology and Neurocognitive Function in Fetal Alcohol Spectrum Disorders
Roussotte, FF, Sulik, KK, Mattson, SN, Riley, EP, Jones, KL, Adnams, CM, May, PA, O’Connor, MJ, Narr, KL, Sowell, ER. Regional Brain Volume Reductions Relate to Facial Dysmorphology and Neurocognitive Function in Fetal Alchohol Spectrum Disorders. Hum Brain Mapp. 2012 April; 33 (4): . doi:10.1002/hbm.21260
Stephen Hursting, Ph.D., M.P.H.
Stephen Hursting, Ph.D., M.P.H. is interested in diet-gene interactions relevant to cancer prevention, particularly the molecular and hormonal mechanisms underlying energy balance-cancer associations.