Environment and Nutrition
Beginning at conception, environmental factors in health can accumulate over a lifetime and be from sources as broad as geographic location and economic status to specific external sources including physical activity, occupation, risky behaviors and diet. But some of these factors, especially in terms of diet are highly modifiable.
Important research is now being conducted on this concept of the “exposome,” as an environmental complement to the human genome. NRI researchers are learning how diet and other environmental exposures interact with disease and affect responses to treatment.
Publications
Environment and Nutrition Publications
2020
Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity. Zeisel S
Perspective: Dietary Biomarkers of Intake and Exposure-Exploration with Omics Approaches. Zeisel S
2019
Obesity and Cancer Metabolism: A Perspective on Interacting Tumor-Intrinsic and Extrinsic Factors. Hursting S
When less may be more: calorie restriction and response to cancer therapy. Hursting S
Energy balance and obesity: what are the main drivers? Hursting S
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Early-Life Predictors of Fetal Alcohol Spectrum Disorders. May P
Alcohol’s Dysregulation of Maternal-Fetal IL-6 and p-STAT3 Is a Function of Maternal Iron Status. Smith S
2018
Energy balance and gastrointestinal cancer: risk, interventions, outcomes and mechanisms. Hursting S
Research Strategies for Nutritional and Physical Activity Epidemiology and Cancer Prevention. Hursting S
2017
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Contribution of Dietary Supplements to Nutritional Adequacy in Various Adult Age Groups. Zeisel S
2016
CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress. Krupenko N
Abnormal Eating Behaviors Are Common in Children with Fetal Alcohol Spectrum Disorder. Smith S
Impact of a western diet on the ovarian and serum metabolome. Sumner S
Metabolomics enables precision medicine: “A White Paper, Community Perspective”. Sumner S
Related News
Diet Gene Interactions Underlie Metabolic Individuality and Influence Brain Development Implications for Clinical Practice
Zeisel, S.H. (2012) Diet-Gene interactions underlie metabolic individuality and influence brain development: implications for clinical practice. Annuals of Nutrition and Metabolism. 60: 19 – 25.
Metabolic Crosstalk between Choline 1 Carbon Metabolism and Energy Homeostasis
Zeisel, S.H. (2012) Metabolic crosstalk between choline/1-carbon metabolism and energy homeostatis. Clinical Chemistry and Laboratory Medicine. doi: 10.1515/cclm-2012-0518. PMID: 23072856.
Choline
Zeisel, S.H., Corbin, K. (2012) Choline. In 10th Edition of Present Knowledge of Nutrition, jointly edited by J.W. Erdman, I.A. MacDonald and S.H. Zeisel,Wiley-Blackwell, Hoboken, NJ. 659 – 681.
Highlights of the 2012 Research Workshop: Using Nutrigenomics and Metabolomics in Clinical Nutrition Research
Zeisel, S.H., Waterland, R.A., Ordovas, J.M., Muoio, D., Jia, W., Fodor, A. (2012) Highlights of the 2012 Research Workshop: Using Nutrigenomics and Metabolomics in Clinical Nutrition Research. Journal of Parenteral and Enteral Nutrition. doi: 10.1177/0148607112462401.
Choline Modern Nutrition in Health and Disease, 11th Ed.
Zeisel, S.H. (2012) Choline. In Modern Nutrition in Health and Disease, 11th Edition. Edited by C. Ross, B. Caballero, R. Cousins, K. Tucker, T. Ziegler, Lippincott Williams & Wilkins, Monkton, VT 416 – 426.
A 45-Minute Vigorous Exercise Bout Increases Metabolic Rate for 14 Hours
Knab, AM, Shanely, RA, Corbin, KD, Jin, F, Nieman, DC. (2011) A 45-min Vigorous Exercise Bout Increases Metabolic Rate for 14 hours. Med Sci Sports Exerc. 43(9):1643-1648. PMID:2131136