Environment and Nutrition
Beginning at conception, environmental factors in health can accumulate over a lifetime and be from sources as broad as geographic location and economic status to specific external sources including physical activity, occupation, risky behaviors and diet. But some of these factors, especially in terms of diet are highly modifiable.
Important research is now being conducted on this concept of the “exposome,” as an environmental complement to the human genome. NRI researchers are learning how diet and other environmental exposures interact with disease and affect responses to treatment.
Publications
Environment and Nutrition Publications
2020
Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity. Zeisel S
Perspective: Dietary Biomarkers of Intake and Exposure-Exploration with Omics Approaches. Zeisel S
2019
Obesity and Cancer Metabolism: A Perspective on Interacting Tumor-Intrinsic and Extrinsic Factors. Hursting S
When less may be more: calorie restriction and response to cancer therapy. Hursting S
Energy balance and obesity: what are the main drivers? Hursting S
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Early-Life Predictors of Fetal Alcohol Spectrum Disorders. May P
Alcohol’s Dysregulation of Maternal-Fetal IL-6 and p-STAT3 Is a Function of Maternal Iron Status. Smith S
2018
Energy balance and gastrointestinal cancer: risk, interventions, outcomes and mechanisms. Hursting S
Research Strategies for Nutritional and Physical Activity Epidemiology and Cancer Prevention. Hursting S
2017
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Contribution of Dietary Supplements to Nutritional Adequacy in Various Adult Age Groups. Zeisel S
2016
CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress. Krupenko N
Abnormal Eating Behaviors Are Common in Children with Fetal Alcohol Spectrum Disorder. Smith S
Impact of a western diet on the ovarian and serum metabolome. Sumner S
Metabolomics enables precision medicine: “A White Paper, Community Perspective”. Sumner S
Related News
Nutritional Genomics: The Need for a Unified and Comprehensive Approach
Niculescu, M. D. (2011) Nutritional Genomics: The Need for a Unified and Comprehensive Approach. J Nutrition Disorder Ther 1, e101
Epigenetic transgenerational inheritance: Should obesity- prevention policies be reconsidered
Niculescu M.D. (2011) Epigenetic transgenerational inheritance: Should obesity-prevention policies be reconsidered? Synesis J, 2, G18-26.
Firsts for an NRI Young Scientist
Tracey He has the distinction of being the first NRI researcher to have earned a master’s degree while working in an NRI lab. Her story is one of passion and dedication.
Maternal Dietary Choline Deficiency Alters Angiogenesis in Fetal Mouse Hippocampus
Niculescu, M. D., Lupu, D. S., and Craciunescu, C. N. (2011) Maternal alpha-linolenic acid availability during gestation and lactation alters the postnatal hippocampal development in the mouse offspring. Int J Dev Neurosci 29, 795-802
Low dose Flaxseed Oil Supplementation Alters the Fatty Acids Profile and the Progression of Metabolic Syndrome in Men without Adequate Medical Treatment
Tint, D., Anghel, M., Lupu, D. S., Fischer, L. M., and Niculescu, M. D. (2011) Low dose Flaxseed Oil Supplementation Alters the Fatty Acids Profile and the Progression of Metabolic Syndrome in Men without Adequate Medical Treatment. J Nutrition Disorder Ther S7, 1
What Choline Metabolism Can Tell Us About the Underlying Mechanism of Fetal Alcohol Spectrum Disorders
Zeisel, S.H. (2011) What choline metabolism can tell us about the underlying mechanisms of fetal alcohol spectrum disorders. Molecular Neurobiology. doi 10.1007/s12035-011-8165-5.