Environment and Nutrition
Beginning at conception, environmental factors in health can accumulate over a lifetime and be from sources as broad as geographic location and economic status to specific external sources including physical activity, occupation, risky behaviors and diet. But some of these factors, especially in terms of diet are highly modifiable.
Important research is now being conducted on this concept of the “exposome,” as an environmental complement to the human genome. NRI researchers are learning how diet and other environmental exposures interact with disease and affect responses to treatment.
Publications
Environment and Nutrition Publications
2020
Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity. Zeisel S
Perspective: Dietary Biomarkers of Intake and Exposure-Exploration with Omics Approaches. Zeisel S
2019
Obesity and Cancer Metabolism: A Perspective on Interacting Tumor-Intrinsic and Extrinsic Factors. Hursting S
When less may be more: calorie restriction and response to cancer therapy. Hursting S
Energy balance and obesity: what are the main drivers? Hursting S
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Early-Life Predictors of Fetal Alcohol Spectrum Disorders. May P
Alcohol’s Dysregulation of Maternal-Fetal IL-6 and p-STAT3 Is a Function of Maternal Iron Status. Smith S
2018
Energy balance and gastrointestinal cancer: risk, interventions, outcomes and mechanisms. Hursting S
Research Strategies for Nutritional and Physical Activity Epidemiology and Cancer Prevention. Hursting S
2017
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Contribution of Dietary Supplements to Nutritional Adequacy in Various Adult Age Groups. Zeisel S
2016
CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress. Krupenko N
Abnormal Eating Behaviors Are Common in Children with Fetal Alcohol Spectrum Disorder. Smith S
Impact of a western diet on the ovarian and serum metabolome. Sumner S
Metabolomics enables precision medicine: “A White Paper, Community Perspective”. Sumner S
Related News
Study Shows Mother’s Diet Affects Child’s Genes
NRI director Dr. Steven Zeisel is co-author of a study showing that a mother’s diet before conception can permanently affect how her child’s genes function. The study has been published in Nature Communications.
Nutrition in Medicine: Nutrition Education for Medical Students and Residents
Adams, K.M., Kohlmeier, M., Powell, M., Zeisel, S.H. (2010) Nutrition in Medicine: Nutrition education for medical students and residents. Nutrition in Clinical Practice. 25(5):471-80.
Nutritional influence on epigenetics and effects on longevity
Niculescu, M.D. & Lupu, D.S. (2011) Nutritional influence on epigenetics and effects on longevity. Curr Opin Clin Nutr Metab Care Jan;14(1):35-40
Adiponectin lowers glucose production by increasing SOGA
Bryan, R.P., Asmar, M.M., Alderman, J.M., Alderman, E.A., Garland, A.L., Busby, W.H., Bodnar, W.M., Rusyn, I., Medoff, B., Tisch, R., Swenberg, J.A., Zeisel, S.H., Combs, T.P. (2010) Adiponectin lowers glucose production by increasing SOGA. American Journal of Pathology. 177(40): 1936-1945. PMCID: PMC2947288.
Alteration of PTGS2 Promoter Methylation in chronic Periodontitis
Zhang, S., Barros, S. P., Niculescu, M. D., Moretti, A. J., Preisser, J. S., and Offenbacher, S. (2010) Alteration of PTGS2 promoter methylation in chronic periodontitis. J Dent Res 89, 133-137
Dose Response Effects of Dermally applied Diethanolamine on Neurogenesis in Fetal Mouse Hippocampus and Potential Exposure of Humans
Mehedint, M.G., Craciunescu, C.N., Zeisel, S.H. (2010) Maternal dietary choline deficiency alters angiogenesis in fetal mouse hippocampus. Proceedings of the National Academy of Sciences USA. 107(29): 12834-39. PMCID: PMC2919920.