Environment and Nutrition
Beginning at conception, environmental factors in health can accumulate over a lifetime and be from sources as broad as geographic location and economic status to specific external sources including physical activity, occupation, risky behaviors and diet. But some of these factors, especially in terms of diet are highly modifiable.
Important research is now being conducted on this concept of the “exposome,” as an environmental complement to the human genome. NRI researchers are learning how diet and other environmental exposures interact with disease and affect responses to treatment.
Publications
Environment and Nutrition Publications
2020
Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity. Zeisel S
Perspective: Dietary Biomarkers of Intake and Exposure-Exploration with Omics Approaches. Zeisel S
2019
Obesity and Cancer Metabolism: A Perspective on Interacting Tumor-Intrinsic and Extrinsic Factors. Hursting S
When less may be more: calorie restriction and response to cancer therapy. Hursting S
Energy balance and obesity: what are the main drivers? Hursting S
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Early-Life Predictors of Fetal Alcohol Spectrum Disorders. May P
Alcohol’s Dysregulation of Maternal-Fetal IL-6 and p-STAT3 Is a Function of Maternal Iron Status. Smith S
2018
Energy balance and gastrointestinal cancer: risk, interventions, outcomes and mechanisms. Hursting S
Research Strategies for Nutritional and Physical Activity Epidemiology and Cancer Prevention. Hursting S
2017
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Contribution of Dietary Supplements to Nutritional Adequacy in Various Adult Age Groups. Zeisel S
2016
CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress. Krupenko N
Abnormal Eating Behaviors Are Common in Children with Fetal Alcohol Spectrum Disorder. Smith S
Impact of a western diet on the ovarian and serum metabolome. Sumner S
Metabolomics enables precision medicine: “A White Paper, Community Perspective”. Sumner S
Related News
February 2019
The Choices I.C.A.N. Make January 25, 2019 – Pregnant women are often consumed by dietary choices such as finding a great prenatal vitamin, eating foods that will promote fetal growth, and doing everything they can to protect their pregnancy. After delivery, however,...
January 2019
Offspring Brain Health Determined by Maternal Diet and Genes December 12, 2018 – The importance of choline to brain development and function was first demonstrated in the 1980s, but because choline has multiple fates and functions within the body, the question of how...
Offspring Brain Health Determined by Maternal Diet and Genes
December 12, 2018 – The importance of choline to brain development and function was first demonstrated in the 1980s, but because choline has multiple fates and functions within the body, the question of how choline levels specifically impacted neural development has remained unanswered. In research just published in The FASEB Journal, NRI director Steven Zeisel, MD PhD, and NRI assistant professor Natalia Surzenko, PhD, make a major contribution towards answering this question.
December 2018
Starving Cells May Lead to New Cancer Treatments November 20, 2018 –Nutrient availability regulates cell metabolism, growth, and survival. When nutrients are in short supply, cells can pause their growth or even eliminate themselves through a process known as...
November 2018
Choline in Human Milk Plays a Crucial Role in Infant Memory October 30, 2018 – Choline is present in human milk, and is especially important for fetal and infant development [2,3]. “The hint that choline is important for infant development comes from the fact that in...
October 2018
Celebrating a Decade of Nutrition Discoveries September 28, 2018 – This October, the NRI proudly marks its tenth anniversary of delving into the science of Precision Nutrition. What began in 2008 with two faculty members and a supporting staff of nine is, today, a...