Environment and Nutrition
Beginning at conception, environmental factors in health can accumulate over a lifetime and be from sources as broad as geographic location and economic status to specific external sources including physical activity, occupation, risky behaviors and diet. But some of these factors, especially in terms of diet are highly modifiable.
Important research is now being conducted on this concept of the “exposome,” as an environmental complement to the human genome. NRI researchers are learning how diet and other environmental exposures interact with disease and affect responses to treatment.
Publications
Environment and Nutrition Publications
2020
Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity. Zeisel S
Perspective: Dietary Biomarkers of Intake and Exposure-Exploration with Omics Approaches. Zeisel S
2019
Obesity and Cancer Metabolism: A Perspective on Interacting Tumor-Intrinsic and Extrinsic Factors. Hursting S
When less may be more: calorie restriction and response to cancer therapy. Hursting S
Energy balance and obesity: what are the main drivers? Hursting S
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Early-Life Predictors of Fetal Alcohol Spectrum Disorders. May P
Alcohol’s Dysregulation of Maternal-Fetal IL-6 and p-STAT3 Is a Function of Maternal Iron Status. Smith S
2018
Energy balance and gastrointestinal cancer: risk, interventions, outcomes and mechanisms. Hursting S
Research Strategies for Nutritional and Physical Activity Epidemiology and Cancer Prevention. Hursting S
2017
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Contribution of Dietary Supplements to Nutritional Adequacy in Various Adult Age Groups. Zeisel S
2016
CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress. Krupenko N
Abnormal Eating Behaviors Are Common in Children with Fetal Alcohol Spectrum Disorder. Smith S
Impact of a western diet on the ovarian and serum metabolome. Sumner S
Metabolomics enables precision medicine: “A White Paper, Community Perspective”. Sumner S
Related News
The continuum of fetal alcohol spectrum disorders in a community in South Africa: Prevalence and characteristics in a fifth sample.
Healthy Cooking for the Holidays: Recipes
November 16, 2016 • Appetite for Life is a series of community programs produced by the NRI brings the latest nutrition science research down to earth in educational and interactive lectures, demonstrations and events. NRI and JWU collaborated to bring the Cooking for Nourishment Demo, Healthy Cooking for the Holidays. See the recipes here.
Mom’s Diet Can Affect Development of Next Two Generations
November 17, 2016 • Nutritional deficiencies during pregnancy can have lasting effects across generations that impact development not only of children, but also of grandchildren. These heritable effects are linked to epigenetic changes that affect gene expression but not DNA sequence. At the NRI, we seek to understand how nutrition affects health and why different people respond differently to the same nutrients.
Nutrition Research Institute Shows Choline is Essential to a Normal Diet
November 1, 2016 • Though it’s present in a variety of foods and an essential part of a person’s diet, many people may not have heard of the nutrient choline.
Researchers from the University of North Carolina at Chapel Hill’s Nutrition Research Institute, located at the NC Research Campus in Kannapolis, have studied the impact that diets lacking in choline could have on everything from liver and muscle tissue to brain development.
November 2015
November 1, 2015 • In this edition of our monthly e-news learn why researchers say no drinking when pregnant, is life expectancy a good measure of health and congratulate Dr. Hursting on his latest award.
November 2016
Do Eggs Cause Heart Disease? Several recent studies linked increased levels of a metabolic product of dietary choline with higher risk of cardiovascular disease (CVD) (Wang et al., 2011; Tang et al., 2013) through a mechanism that involved gut microbiota-produced...