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Natalia Krupenko, PhD

natalia_krupenko@unc.edu
704-250-5054

Biography
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Natalia Krupenko, PhD

Associate Professor of Nutrition

Natalia Krupenko, PhD, Associate Professor of Nutrition, joined the UNC Nutrition Research Institute in April 2014. Dr. Krupenko’s research is focused on the role of folate (vitamin B9) in promoting health and preventing disease in humans. Folate deficiency has been connected with increased risk for neural tube defects, cardiovascular disease, and cancer. Recently, however, concerns have been raised regarding the adverse effects of over-supplementation with the vitamin. Dr. Krupenko’s goal is to determine the best ways to utilize health-protective properties of folate and prevent the possibility of its adverse effects in humans.

Dr. Krupenko’s work is covered in 35 peer-reviewed publications in high-impact journals and numerous presentations at national and international conferences and meetings. Dr. Krupenko earned her doctorate degree in bioorganic chemistry from the Institute of Bioorganic Chemistry, Byelorussian Academy of Sciences, in Minsk, Belarus.  She was a recipient of the Rockefeller Foundation Fellowship in Population Sciences and served on the faculty of the Medical University of South Carolina. In addition to her role at the NRI, Dr. Krupenko holds an appointment as an Associate Professor in the Department of Nutrition at the Gillings School of Global Public Health, UNC-Chapel Hill.

Natalia Krupenko, PhD, Associate Professor of Nutrition, joined the UNC Nutrition Research Institute in April 2014. Dr. Krupenko’s research is focused on the role of folate (vitamin B9) in promoting health and preventing disease in humans. Folate deficiency has been connected with increased risk for neural tube defects, cardiovascular disease, and cancer. Recently, however, concerns have been raised regarding the adverse effects of over-supplementation with the vitamin. Dr. Krupenko’s goal is to determine the best ways to utilize health-protective properties of folate and prevent the possibility of its adverse effects in humans.

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Dr. Krupenko’s work is covered in 35 peer-reviewed publications in high-impact journals and numerous presentations at national and international conferences and meetings. Dr. Krupenko earned her doctorate in bioorganic chemistry from the Institute of Bioorganic Chemistry, Byelorussian Academy of Sciences, in Minsk, Belarus.  She was a recipient of the Rockefeller Foundation Fellowship in Population Sciences and served on the faculty of the Medical University of South Carolina. Currently, in addition to her role at the NRI, Dr. Krupenko holds her appointment as an Associate Professor with the Department of Nutrition at the Gillings School of Global Public Health, UNC-Chapel Hill.

Krupenko’s Team

Madeline Hall Childress

Graduate Student, N. Krupenko Lab

  • madeline_hall@unc.edu
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In the News

Natalia Krupenko, Ph.D.

Jun 25, 2014

Next Entries »

Publications

2025

Probing the metabolic regulator and candidate tumor suppressor ALDH1L1 as a target for non-small cell lung cancer gene therapy

Differential Expression of One-Carbon Pathway Enzyme ALDH1L1 Is Linked to Tumorigenicity of Low-Grade Bladder Cancer Cells Through Metabolic Reprogramming

2024

Further Delineation of the Phenotypic and Metabolomic Profile of ALDH1L2-Related Neurodevelopmental Disorder

2023

Pancreatic Islet Protection at the Expense of Secretory Function Involves Serine-Linked Mitochondrial One-Carbon Metabolism

2022

Structure of Putative Tumor Suppressor ALDH1L1

Sex-Specific Metabolic Effects of Dietary Folate Withdrawal in Wild-Type and Aldh1l1 Knockout Mice

Exploratory Metabolomics Underscores the Folate Enzyme ALDH1L1 as a Regulator of Glycine and Methylation Reactions

2021

Knockout of Putative Tumor Suppressor Aldh1l1 in Mice Reprograms Metabolism to Accelerate Growth of Tumors in a Diethylnitrosamine (DEN) Model of Liver Carcinogenesis

2020
Sphingolipids and the Link Between Alcohol and Cancer
2019
Cytosolic 10-formyltetrahydrofolate dehydrogenase regulates glycine metabolism in mouse liver.

Deleterious mutations in ALDH1L2 suggest a novel cause for neuro-ichthyotic syndrome.

Loss of ALDH1L1 folate enzyme confers a selective metabolic advantage for tumor progression.

2018

ALDH1L1 and ALDH1L2 Folate Regulatory Enzymes in Cancer.

C16-ceramide is a natural regulatory ligand of p53 in cellular stress response.

Ceramide Synthase 6: Comparative Analysis, Phylogeny and Evolution.

Ceramide Signaling and p53 Pathways.

CHIP E3 ligase mediates proteasomal degradation of the proliferation regulatory protein ALDH1L1 during the transition of NIH3T3 fibroblasts from G0/G1 to S-phase.

2016

CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress.

Ceramide Synthase 6 Is a Novel Target of Methotrexate Mediating Its Antiproliferative Effect in a p53-Dependent Manner.

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