Genes and Nutrition
Each of us is metabolically unique. Gene variations known as SNPs (single nucleotide polymorphisms) often are a factor in an individual’s ability to metabolize or use nutrients efficiently. Each of our specific nutrient needs is affected by which specific combination of SNPs we have, but with thousands known to impact nutrition metabolism, how do we know what those needs are?
NRI researchers are working to create a “catalog” of SNPs that alter our nutritional needs by understanding how genetic and other complex biological information can be used to better estimate individual nutrition requirements and intolerances. Our scientists use bioinformatics to extract such information from population and intervention studies, develop rules for predicting individual needs, and bring precision nutrition to health care providers and consumers with digital tools.
Publications
Genes and Nutrition Publications
2020
Genetic variants affecting bone mineral density and bone mineral content at multiple skeletal sites in Hispanic children. Voruganti VS
Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity. Zeisel S
2019
DNA methylation in mice is influenced by genetics as well as sex and life experience. French J
Cytosolic 10-formyltetrahydrofolate dehydrogenase regulates glycine metabolism in mouse liver. Krupenko S
Deleterious mutations in ALDH1L2 suggest a novel cause for neuro-ichthyotic syndrome. Krupenko S
Fine mapping and identification of serum urate loci in American Indians: The Strong Heart Family Study. Voruganti VS
Heterogeneity in Metabolic Responses to Dietary Fructose. Voruganti VS
Genetic analysis of hsCRP in American Indians: The Strong Heart Family Study. Voruganti VS
A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity. Voruganti VS
Healthy dietary patterns and risk and survival of breast cancer: a meta-analysis of cohort studies. Voruganti VS
Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10-Pulmonary Function Association. Voruganti VS
2018
C16-ceramide is a natural regulatory ligand of p53 in cellular stress response. Krupenko N
Nutritional Genomics of Cardiovascular Disease. Voruganti VS
Genetic determinants of BMI from early childhood to adolescence: the Santiago Longitudinal Study. Voruganti VS
Serum Lipid Concentrations and FADS Genetic Variants in Young Mexican College Students: The UP-AMIGOS Cohort Study. Voruganti VS
Arsenic-gene interactions and beta-cell function in the Strong Heart Family Study. Voruganti VS
Dietary Modulation of the Epigenome. Zeisel S
2017
Exome sequencing reveals novel genetic loci influencing obesity-related traits in Hispanic children. Voruganti VS
Genetic variation underlying renal uric acid excretion in Hispanic children: the Viva La Familia Study. Voruganti VS
Reduced brain volume and impaired memory in betaine homocysteine S-methyltransferase knockout mice. Zeisel S
Choline, Other Methyl-Donors and Epigenetics. Zeisel S
2016
CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress. Krupenko N
Genotype, B-vitamin status, and androgens affect spaceflight-induced ophthalmic changes. Zeisel S
Related News
Ammerman to co-lead UNC’s new campus theme – ‘Food for All’
May 4, 2015 • Members of the UNC-Chapel Hill community will come together at a common table when they examine food studies as UNC’s 2015-2017 university-wide academic theme.
“Food for All: Local and Global Perspectives,” which builds on UNC’s 2012-2015 “Water in Our World” focus on global water issues, will challenge all areas of the university to examine wide-ranging topics from food cultures and nutrition, to food security, world hunger, agricultural economics, resource management, sustainable development, climate change and international trade.
May 2015
May 6, 2015 • May 2015’s SoundBites features: Renowned Nutrition Scientist Speaks on Longevity; Nutrient Bar Results in Broadscale Health Improvements After Only Two Months; Eat More Produce, Reduce Cancer; and the Lettuce Eat Café
Nutrient Bar Results in Broadscale Health Improvements After Only Two Months
May 1, 2015 • A fruit-based micronutrient and fiber-dense supplement bar (the “CHORI-bar”), conceived by Drs. Bruce Ames and Mark K. Shigenaga at Children’s Hospital Oakland Research Institute (CHORI), was shown in clinical trials to improve metabolism in overweight/obese (OW/OB) otherwise healthy adults in ways that are consistent with reduced risk of type 2 diabetes and cardiovascular disease. Consumption of the bar for two months also reduced chronic inflammation, and initiated a reduction in weight and waist circumference. Decreased inflammation and improved weight and weight distribution can lower the risk of many chronic diseases.
UNC-Chapel Hill explores “Food for All” with 2015-2017 campus theme
April 30, 2015 • The University of North Carolina at Chapel Hill will come together at a common table when it examines food and food studies as its 2015-2017 university-wide academic theme. “Food for All: Local and Global Perspectives,” which builds on Carolina’s 2012-2015 “Water in Our World” focus on global water issues, will challenge all areas of the University to examine wide-ranging topics from food cultures and nutrition, to food security, world hunger, agricultural economics, resource management, sustainable development, climate change and international trade.
Eat More Produce, Reduce Cancer
April 29, 2015 • It’s spring! Farmers markets are opening and these are great places to find a variety of local, seasonal produce, which flourishes now. Making room for these powerhouses in your everyday food choices is important for your health. A 2012 peer-reviewed analysis in Food and Chemical Toxicology states that approximately 20,000 cancer cases could be prevented every year if one-half of Americans were to increase their serving of fruits and vegetables by one serving per day.
Vitamins and Healthy Diet
Dr. Natalia Krupenko addresses vitamin supplementation and its effects on the human body.