Genes and Nutrition
Each of us is metabolically unique. Gene variations known as SNPs (single nucleotide polymorphisms) often are a factor in an individual’s ability to metabolize or use nutrients efficiently. Each of our specific nutrient needs is affected by which specific combination of SNPs we have, but with thousands known to impact nutrition metabolism, how do we know what those needs are?
NRI researchers are working to create a “catalog” of SNPs that alter our nutritional needs by understanding how genetic and other complex biological information can be used to better estimate individual nutrition requirements and intolerances. Our scientists use bioinformatics to extract such information from population and intervention studies, develop rules for predicting individual needs, and bring precision nutrition to health care providers and consumers with digital tools.
Publications
Genes and Nutrition Publications
2020
Genetic variants affecting bone mineral density and bone mineral content at multiple skeletal sites in Hispanic children. Voruganti VS
Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity. Zeisel S
2019
DNA methylation in mice is influenced by genetics as well as sex and life experience. French J
Cytosolic 10-formyltetrahydrofolate dehydrogenase regulates glycine metabolism in mouse liver. Krupenko S
Deleterious mutations in ALDH1L2 suggest a novel cause for neuro-ichthyotic syndrome. Krupenko S
Fine mapping and identification of serum urate loci in American Indians: The Strong Heart Family Study. Voruganti VS
Heterogeneity in Metabolic Responses to Dietary Fructose. Voruganti VS
Genetic analysis of hsCRP in American Indians: The Strong Heart Family Study. Voruganti VS
A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity. Voruganti VS
Healthy dietary patterns and risk and survival of breast cancer: a meta-analysis of cohort studies. Voruganti VS
Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10-Pulmonary Function Association. Voruganti VS
2018
C16-ceramide is a natural regulatory ligand of p53 in cellular stress response. Krupenko N
Nutritional Genomics of Cardiovascular Disease. Voruganti VS
Genetic determinants of BMI from early childhood to adolescence: the Santiago Longitudinal Study. Voruganti VS
Serum Lipid Concentrations and FADS Genetic Variants in Young Mexican College Students: The UP-AMIGOS Cohort Study. Voruganti VS
Arsenic-gene interactions and beta-cell function in the Strong Heart Family Study. Voruganti VS
Dietary Modulation of the Epigenome. Zeisel S
2017
Exome sequencing reveals novel genetic loci influencing obesity-related traits in Hispanic children. Voruganti VS
Genetic variation underlying renal uric acid excretion in Hispanic children: the Viva La Familia Study. Voruganti VS
Reduced brain volume and impaired memory in betaine homocysteine S-methyltransferase knockout mice. Zeisel S
Choline, Other Methyl-Donors and Epigenetics. Zeisel S
2016
CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress. Krupenko N
Genotype, B-vitamin status, and androgens affect spaceflight-induced ophthalmic changes. Zeisel S
Related News
Metabolic Effects of Vitamin D Deficiency: A Mouse Model of Precision Nutrition
The fundamental principle of precision nutrition is that different people, by virtue of their genetic backgrounds and life exposures, may have different nutritional needs. A compelling example of this principle is found in a recent publication by current NRI faculty...
Obesity Linked with Higher Risk for COVID-19 Complications
This article was published originally by UNC-Chapel Hill in Health and Medicine on Wednesday, August 26th, 2020. A review of COVID-19 studies reveals a troubling connection between two health crises: coronavirus and obesity. From COVID-19 risk to recovery, the odds...
September 2020
Precision Nutrition–the Answer to "What to Eat to Stay Healthy" August 28, 2020 – From an opinion paper in the Journal of the American Medical Association by Griffin P. Rodgers, MD, and Francis S. Collins, MD, PhD for NIH. The long-recognized centrality and importance...
Research Uncovered: Baba Mass
This article was published originally by endeavors on August 19th, 2020. Baba Mass is a research technician in the Voruganti Lab within the UNC Nutrition Research Institute. He studies how genes and diet impact serum uric acid levels – a chemical created when the body...
Precision Nutrition—the Answer to “What to Eat to Stay Healthy”
This article was published originally online in the Journal of the American Medical Association on August 7, 2020. By Griffin P. Rodgers, MD and Francis S. Collins, MD, PhD, National Institutes of Health, Bethesda, MD The long-recognized centrality and importance of...
Matching Meals to Metabolism
This article was originally published on knowablemagazine.org on July 28, 2020. By Jyoti Madhusoodanan Q&A with nutrition researcher Steven Zeisel Genes, microbes and other factors govern how each person’s body processes nutrients. Understanding the connections...