Genes and Nutrition
Each of us is metabolically unique. Gene variations known as SNPs (single nucleotide polymorphisms) often are a factor in an individual’s ability to metabolize or use nutrients efficiently. Each of our specific nutrient needs is affected by which specific combination of SNPs we have, but with thousands known to impact nutrition metabolism, how do we know what those needs are?
NRI researchers are working to create a “catalog” of SNPs that alter our nutritional needs by understanding how genetic and other complex biological information can be used to better estimate individual nutrition requirements and intolerances. Our scientists use bioinformatics to extract such information from population and intervention studies, develop rules for predicting individual needs, and bring precision nutrition to health care providers and consumers with digital tools.
Publications
Genes and Nutrition Publications
2020
Genetic variants affecting bone mineral density and bone mineral content at multiple skeletal sites in Hispanic children. Voruganti VS
Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity. Zeisel S
2019
DNA methylation in mice is influenced by genetics as well as sex and life experience. French J
Cytosolic 10-formyltetrahydrofolate dehydrogenase regulates glycine metabolism in mouse liver. Krupenko S
Deleterious mutations in ALDH1L2 suggest a novel cause for neuro-ichthyotic syndrome. Krupenko S
Fine mapping and identification of serum urate loci in American Indians: The Strong Heart Family Study. Voruganti VS
Heterogeneity in Metabolic Responses to Dietary Fructose. Voruganti VS
Genetic analysis of hsCRP in American Indians: The Strong Heart Family Study. Voruganti VS
A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity. Voruganti VS
Healthy dietary patterns and risk and survival of breast cancer: a meta-analysis of cohort studies. Voruganti VS
Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10-Pulmonary Function Association. Voruganti VS
2018
C16-ceramide is a natural regulatory ligand of p53 in cellular stress response. Krupenko N
Nutritional Genomics of Cardiovascular Disease. Voruganti VS
Genetic determinants of BMI from early childhood to adolescence: the Santiago Longitudinal Study. Voruganti VS
Serum Lipid Concentrations and FADS Genetic Variants in Young Mexican College Students: The UP-AMIGOS Cohort Study. Voruganti VS
Arsenic-gene interactions and beta-cell function in the Strong Heart Family Study. Voruganti VS
Dietary Modulation of the Epigenome. Zeisel S
2017
Exome sequencing reveals novel genetic loci influencing obesity-related traits in Hispanic children. Voruganti VS
Genetic variation underlying renal uric acid excretion in Hispanic children: the Viva La Familia Study. Voruganti VS
Reduced brain volume and impaired memory in betaine homocysteine S-methyltransferase knockout mice. Zeisel S
Choline, Other Methyl-Donors and Epigenetics. Zeisel S
2016
CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress. Krupenko N
Genotype, B-vitamin status, and androgens affect spaceflight-induced ophthalmic changes. Zeisel S
Related News
September AFL Program Recap: “Good Bowls: A social venture to improve healthy food access”
September 25, 2019 – If you missed September’s Appetite for Life presentation by Alice Ammerman, DrPH, you can catch up. Watch the entire program on video now. The live presentation took place at the Rowan-Cabarrus Community College Biotechnology Training Center in Kannapolis on Wednesday, September 18, 2019.
December 2019
If food is medicine, why isn’t it taught at medical schools? November 14, 2019 – In a new report published by the Harvard Food Law and Policy Clinic, researchers write that, on average, students in medical schools across the country spend less than 1 percent of...
November 2019
Saroja Voruganti, PhD, Promoted to Associate Professor October 22, 2019 – Saroja Voruganti, PhD, was recently promoted to the rank of Associate Professor in the Department of Nutrition at the University of North Carolina at Chapel Hill. Nutrition Research Institute...
October 2019
Choline must be integrated into the prenatal supplement regimen, says expert review September 16, 2019 – This article was published originally on nutraingredients-usa.com on September 11, 2019. By Stephen Daniels The importance of choline during the first 1,000 days...
Hursting moves into 16th year of Breast Cancer Research Foundation grant
September 17, 2019 – “Our work has evolved from asking Is obesity increasing cancer risk? and What are the mechanisms linking obesity and cancer?” he says. “We have largely answered the first question and are still working on the second, but our focus really has turned to What are we going to do about it?”
Choline must be integrated into the prenatal supplement regimen, says expert review
This article was published originally on nutraingredients-usa.com on September 11, 2019. By Stephen Daniels The importance of choline during the first 1,000 days after conception is increasingly understood by the medical community, and dietary supplement manufacturers...