Genes and Nutrition
Each of us is metabolically unique. Gene variations known as SNPs (single nucleotide polymorphisms) often are a factor in an individual’s ability to metabolize or use nutrients efficiently. Each of our specific nutrient needs is affected by which specific combination of SNPs we have, but with thousands known to impact nutrition metabolism, how do we know what those needs are?
NRI researchers are working to create a “catalog” of SNPs that alter our nutritional needs by understanding how genetic and other complex biological information can be used to better estimate individual nutrition requirements and intolerances. Our scientists use bioinformatics to extract such information from population and intervention studies, develop rules for predicting individual needs, and bring precision nutrition to health care providers and consumers with digital tools.
Publications
Genes and Nutrition Publications
2020
Genetic variants affecting bone mineral density and bone mineral content at multiple skeletal sites in Hispanic children. Voruganti VS
Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity. Zeisel S
2019
DNA methylation in mice is influenced by genetics as well as sex and life experience. French J
Cytosolic 10-formyltetrahydrofolate dehydrogenase regulates glycine metabolism in mouse liver. Krupenko S
Deleterious mutations in ALDH1L2 suggest a novel cause for neuro-ichthyotic syndrome. Krupenko S
Fine mapping and identification of serum urate loci in American Indians: The Strong Heart Family Study. Voruganti VS
Heterogeneity in Metabolic Responses to Dietary Fructose. Voruganti VS
Genetic analysis of hsCRP in American Indians: The Strong Heart Family Study. Voruganti VS
A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity. Voruganti VS
Healthy dietary patterns and risk and survival of breast cancer: a meta-analysis of cohort studies. Voruganti VS
Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10-Pulmonary Function Association. Voruganti VS
2018
C16-ceramide is a natural regulatory ligand of p53 in cellular stress response. Krupenko N
Nutritional Genomics of Cardiovascular Disease. Voruganti VS
Genetic determinants of BMI from early childhood to adolescence: the Santiago Longitudinal Study. Voruganti VS
Serum Lipid Concentrations and FADS Genetic Variants in Young Mexican College Students: The UP-AMIGOS Cohort Study. Voruganti VS
Arsenic-gene interactions and beta-cell function in the Strong Heart Family Study. Voruganti VS
Dietary Modulation of the Epigenome. Zeisel S
2017
Exome sequencing reveals novel genetic loci influencing obesity-related traits in Hispanic children. Voruganti VS
Genetic variation underlying renal uric acid excretion in Hispanic children: the Viva La Familia Study. Voruganti VS
Reduced brain volume and impaired memory in betaine homocysteine S-methyltransferase knockout mice. Zeisel S
Choline, Other Methyl-Donors and Epigenetics. Zeisel S
2016
CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress. Krupenko N
Genotype, B-vitamin status, and androgens affect spaceflight-induced ophthalmic changes. Zeisel S
Related News
June 2018
NRI Included in UNC Creativity Hubs Inaugural Award to Study Obesity May 30, 2018 – Five NRI faculty members are among a team of UNC researchers receiving an award to study one of the world's most pressing issues: the obesity epidemic. The cross-disciplinary team,...
New Grant to Study Nutrition and Chemotherapeutic Response
May 30, 2018 – Delisha Stewart, PhD, Assistant Professor of Nutrition at the UNC Nutrition Research Institute, has been awarded a two year grant to study the impact of diet on chemotherapeutic treatment resistance in obesity-driven, aggressive breast cancer. This award builds from the research Dr. Stewart has conducted over the last ten years.
NRI Included in UNC Creativity Hubs Inaugural Award to Study Obesity
May 14, 2018 – Five NRI faculty members are among a team of UNC researchers receiving an award to study one of the world’s most pressing issues: the obesity epidemic. The cross-disciplinary team, known as the Heterogeneity in Obesity Creativity Hub, will leverage the strengths of Carolina’s schools of medical and health sciences, affiliated research centers and institutes, and prowess in big data management to take a novel approach to assess the underlying causes of obesity to unlock new, targeted ways to treat the disease.
May 2018
The Connection Between Diet, Obesity and Cancer April 30, 2018 –Obesity prevalence in the US has tripled over the last 50 years. In 2016, a report by the International Agency for Research on Cancer highlighted that excess body fatness increases the risk for 13 types...
The connection between diet, obesity, and cancer: Nutrition experts explore the evidence
April 26, 2018 -About one third of cancer cases are estimated to be linked to dietary and other modifiable risk factors, especially for obesity-related cancers such as breast, colorectal, ovarian, endometrial, kidney, gallbladder, esophageal, and pancreatic cancers. In this special theme issue of the Journal of the Academy of Nutrition and Dietetics, food and nutrition practitioners and other health professionals take an in-depth look at the relationship between nutrition, obesity, and cancer prevention, treatment, and survival and identify research gaps for future prevention research efforts.
NRI Expert Discusses Genetics and Weight Loss in Prevention Magazine
April 26, 2018 – Joanne Laird had struggled with obesity for her entire life. She’d tried every diet under the sun, but it wasn’t until last June, when she received the results of an at-home DNA test, that she was finally able to shed the extra pounds.