Genes and Nutrition
Each of us is metabolically unique. Gene variations known as SNPs (single nucleotide polymorphisms) often are a factor in an individual’s ability to metabolize or use nutrients efficiently. Each of our specific nutrient needs is affected by which specific combination of SNPs we have, but with thousands known to impact nutrition metabolism, how do we know what those needs are?
NRI researchers are working to create a “catalog” of SNPs that alter our nutritional needs by understanding how genetic and other complex biological information can be used to better estimate individual nutrition requirements and intolerances. Our scientists use bioinformatics to extract such information from population and intervention studies, develop rules for predicting individual needs, and bring precision nutrition to health care providers and consumers with digital tools.
Publications
Genes and Nutrition Publications
2020
Genetic variants affecting bone mineral density and bone mineral content at multiple skeletal sites in Hispanic children. Voruganti VS
Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity. Zeisel S
2019
DNA methylation in mice is influenced by genetics as well as sex and life experience. French J
Cytosolic 10-formyltetrahydrofolate dehydrogenase regulates glycine metabolism in mouse liver. Krupenko S
Deleterious mutations in ALDH1L2 suggest a novel cause for neuro-ichthyotic syndrome. Krupenko S
Fine mapping and identification of serum urate loci in American Indians: The Strong Heart Family Study. Voruganti VS
Heterogeneity in Metabolic Responses to Dietary Fructose. Voruganti VS
Genetic analysis of hsCRP in American Indians: The Strong Heart Family Study. Voruganti VS
A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity. Voruganti VS
Healthy dietary patterns and risk and survival of breast cancer: a meta-analysis of cohort studies. Voruganti VS
Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10-Pulmonary Function Association. Voruganti VS
2018
C16-ceramide is a natural regulatory ligand of p53 in cellular stress response. Krupenko N
Nutritional Genomics of Cardiovascular Disease. Voruganti VS
Genetic determinants of BMI from early childhood to adolescence: the Santiago Longitudinal Study. Voruganti VS
Serum Lipid Concentrations and FADS Genetic Variants in Young Mexican College Students: The UP-AMIGOS Cohort Study. Voruganti VS
Arsenic-gene interactions and beta-cell function in the Strong Heart Family Study. Voruganti VS
Dietary Modulation of the Epigenome. Zeisel S
2017
Exome sequencing reveals novel genetic loci influencing obesity-related traits in Hispanic children. Voruganti VS
Genetic variation underlying renal uric acid excretion in Hispanic children: the Viva La Familia Study. Voruganti VS
Reduced brain volume and impaired memory in betaine homocysteine S-methyltransferase knockout mice. Zeisel S
Choline, Other Methyl-Donors and Epigenetics. Zeisel S
2016
CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress. Krupenko N
Genotype, B-vitamin status, and androgens affect spaceflight-induced ophthalmic changes. Zeisel S
Related News
Should You Exercise When You’re Sick?
February 26, 2018 – ASU Human Performance Lab Director David Nieman, DrPH, was featured in a Time article discussing exercise and the immune system. “Your immune system needs activity to do its job better. Every time you exercise, you increase the circulation of important immune cells.” However, he emphasizes, that while “exercise is great for prevention, it’s not as helpful when you’re already sick.”
Do you have the cure for the common cold?
February 26, 2018 – Everyone gets the common cold; hence, its name. Why isn’t there a cure or preventative vaccine? Actually there is, and you have it already – an active lifestyle including regular physical activity. David Nieman, DrPH, FACSM, the director of the Appalachian State University Human Performance Laboratory at the NC Research Campus, explains.
Choline Biomarker Study Wins Federal Support
February 7, 2018 – UNC Nutrition Research Institute director Steven H. Zeisel, MD, PhD has been awarded a four-year, $2.6 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), one of the National Institutes of Health, to develop and validate a panel of laboratory tests that can assess choline status in humans.
Study of first-graders shows fetal alcohol spectrum disorders prevalent in US communities
February 6, 2018 – Philip A. May, PhD, research professor at the UNC Nutrition Research Institute, led NIH-funded research that examined over 6,000 children to determine prevalence of FASD ranged from 1.1 to 5 percent.
A new study of more than 6,000 first-graders across four U.S. communities has found that a significant number of the children examined, as many as 5 percent in one community sample, may have fetal alcohol spectrum disorders (FASD). Funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health, the new findings may represent more accurate prevalence estimates of FASD among general U.S. communities than prior research. Previous FASD estimates were based on smaller study populations and do not reflect the overall U.S. population.
February 2018
Whole Foods and Nutrient Synergy January 29, 2018 – Have you ever wondered why we eat certain foods together? What is it about pork that demands applesauce? Wouldn’t a lovely piece of hard cheese go well with that glass of red wine? Is beef and broccoli just a dish or...