Genes and Nutrition

Each of us is metabolically unique. Gene variations known as SNPs (single nucleotide polymorphisms) often are a factor in an individual’s ability to metabolize or use nutrients efficiently. Each of our specific nutrient needs is affected by which specific combination of SNPs we have, but with thousands known to impact nutrition metabolism, how do we know what those needs are?

NRI researchers are working to create a “catalog” of SNPs that alter our nutritional needs by understanding how genetic and other complex biological information can be used to better estimate individual nutrition requirements and intolerances. Our scientists use bioinformatics to extract such information from population and intervention studies, develop rules for predicting individual needs, and bring precision nutrition to health care providers and consumers with digital tools.

Publications

 

Genes and Nutrition Publications

2020

Genetic variants affecting bone mineral density and bone mineral content at multiple skeletal sites in Hispanic children.  Voruganti VS

Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity.  Zeisel S

2019

DNA methylation in mice is influenced by genetics as well as sex and life experience.  French J

Cytosolic 10-formyltetrahydrofolate dehydrogenase regulates glycine metabolism in mouse liver.  Krupenko S

Deleterious mutations in ALDH1L2 suggest a novel cause for neuro-ichthyotic syndrome.  Krupenko S

Fine mapping and identification of serum urate loci in American Indians: The Strong Heart Family Study.  Voruganti VS

Heterogeneity in Metabolic Responses to Dietary Fructose.  Voruganti VS

Genetic analysis of hsCRP in American Indians: The Strong Heart Family Study.  Voruganti VS

A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity.  Voruganti VS

Healthy dietary patterns and risk and survival of breast cancer: a meta-analysis of cohort studies.  Voruganti VS

Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10-Pulmonary Function Association.  Voruganti VS

Betaine-homocysteine S-methyltransferase deficiency causes increased susceptibility to noise-induced hearing loss associated with plasma hyperhomocysteinemia.  Zeisel S

MicroRNA-129-5p is regulated by choline availability and controls EGF receptor synthesis and neurogenesis in the cerebral cortex.  Zeisel S

2018

Introduction to mammalian genome special issue: the combined role of genetics and environment relevant to human disease outcomes.  French J

C16-ceramide is a natural regulatory ligand of p53 in cellular stress response.  Krupenko N

Metabolic Phenotype of Wild-Type and As3mt-Knockout C57BL/6J Mice Exposed to Inorganic Arsenic: The Role of Dietary Fat and Folate Intake.  Krupenko S

Nutritional Genomics of Cardiovascular Disease.  Voruganti VS

Genetic determinants of BMI from early childhood to adolescence: the Santiago Longitudinal Study.  Voruganti VS

Genetic Variants Related to Cardiometabolic Traits Are Associated to B Cell Function, Insulin Resistance, and Diabetes Among AmeriCan Indians: The Strong Heart Family Study.  Voruganti VS

Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function.  Voruganti VS

Serum Lipid Concentrations and FADS Genetic Variants in Young Mexican College Students: The UP-AMIGOS Cohort Study.  Voruganti VS

Arsenic-gene interactions and beta-cell function in the Strong Heart Family Study.  Voruganti VS

Dietary Modulation of the Epigenome.  Zeisel S

2017

NTP Research Report on Absence of Formaldehyde-Induced Neoplasia in Trp53 Haploinsufficient Mice Exposed by Inhalation: Research Report 3 [Internet].  French J

QTL Mapping and Identification of Candidate Genes in DO Mice: A Use Case Model Derived from a Benzene Toxicity Experiment.  French J

Heterogeneity of p53 dependent genomic responses following ethanol exposure in a developmental mouse model of fetal alcohol spectrum disorder.  Mooney S

Exome sequencing reveals novel genetic loci influencing obesity-related traits in Hispanic children.  Voruganti VS

Genetic variation underlying renal uric acid excretion in Hispanic children: the Viva La Familia Study.  Voruganti VS

Reduced brain volume and impaired memory in betaine homocysteine S-methyltransferase knockout mice.  Zeisel S

Betaine is accumulated via transient choline dehydrogenase activation during mouse oocyte meiotic maturation.  Zeisel S

Deletion of one allele of Mthfd1 (methylenetetrahydrofolate dehydrogenase 1) impairs learning in mice.  Zeisel S

Choline, Other Methyl-Donors and Epigenetics.  Zeisel S

Choline and its metabolites are differently associated with cardiometabolic risk factors, history of cardiovascular disease, and MRI-documented cerebrovascular disease in older adults.  Zeisel S

Altered methylation of specific DNA loci in the liver of Bhmt-null mice results in repression of Iqgap2 and F2rl2 and is associated with development of preneoplastic foci.  Zeisel S

2016

CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress.  Krupenko N

Genotype, B-vitamin status, and androgens affect spaceflight-induced ophthalmic changes.  Zeisel S

Related News

Female Tea Drinkers See Epigenetic Changes in Cancer and Hormone Genes

June 27, 2017 • That morning or midday beverage may have a greater effect on our genes than previously thought, especially if you happen to be female and consume tea on a regular basis. New evidence from a group of investigators at Uppsala University shows that tea consumption in women leads to epigenetic changes in genes that are known to interact with cancer and estrogen metabolism. Findings from the new study were published recently in Human Molecular Genetics in an article entitled “Tea and Coffee Consumption in Relation to DNA Methylation in Four European Cohorts.”

NRI Grooms Next Gen Scientists

June 27, 2017 • Grant Canipe didn’t always know that he wanted to be a scientist. His revelation came one day at Northwest Cabarrus High School in Concord, NC, when a Duke University student came to Canipe’s AP biology class to discuss his research and plans for graduate school. Canipe found himself inspired by that student’s experience so much that he himself is now completing his doctorate at UNC Chapel Hill in developmental psychology and nutrition. He studies under the direction of Carol L. Cheatham, Ph.D. in the Cheatham Nutrition & Cognition Laboratory at the UNC Nutrition Research Institute (NRI), located on the North Carolina Research Campus in Kannapolis. […]

July 2017

NRI Grooms Next Gen Scientists When Grant Canipe graduated from Northwest Cabarrus in 2009, he joked that he was leaving Concord and never coming back. But in an interesting twist, he did come back and is now working as a scientist at the UNC Nutrition Research...

University of North Carolina Introduces New Research Core Merging Nutrition And Genetics

June 1, 2017 • The University of North Carolina Nutrition and Obesity Research Center (NORC) introduces the new Nutrigenetics and Nutrigenomics (NGx) Core. Located in the UNC Nutrition Research Institute (NRI) on the NC Research Campus in Kannapolis, NGx has been created to assist investigators in conducting studies that lead to a better understanding of the impacts lifestyle and genetics have […]

Know Your Neurotransmitters: Acetylcholine

June 1, 2017 • It’s high time we covered acetylcholine — the most plentiful neurotransmitter in the body. And our Know Your Neurotransmitters series continues with the best guest possible to talk to us about acetylcholine: Dr. Steven Zeisel, MD, PhD. Dr. Zeisel, UNC Nutrition Research Institute Director, was involved in the first study of the effects of choline — the nutrient precursor to acetylcholine — on humans […]

June 2017

Know Your Neurotransmitters: Acetylcholine It’s high time we covered acetylcholine — the most plentiful neurotransmitter in the body. And our Know Your Neurotransmitters series continues with the best guest possible to talk to us about acetylcholine: Dr. Steven...