Microbiome and Nutrition

The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.

Publications

 

Microbiome and Nutrition Publications

2020

Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K

2019

Association of dietary patterns with the gut microbiota in older, community-dwelling men.  Meyer K

The impact of early-life sub-therapeutic antibiotic treatment (STAT) on excessive weight is robust despite transfer of intestinal microbes.  Sumner S

Protein Intake at Twice the RDA in Older Men Increases Circulatory Concentrations of the Microbiome Metabolite Trimethylamine-N-Oxide (TMAO).  Zeisel S

2018

Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative.  Meyer K

Human microbiota, blood group antigens, and disease.  Sumner S

2017

Dietary Choline and Betaine and Risk of CVD: A Systematic Review and Meta-Analysis of Prospective Studies.  Meyer K

A Microbiomic Analysis in African Americans with Colonic Lesions Reveals Streptococcus sp.VT162 as a Marker of Neoplastic Transformation.  Sumner S

Metabolic profiling of a chronic kidney disease cohort reveals metabolic phenotype more likely to benefit from a probiotic.  Sumner S

Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease.  Zeisel S

2016

Microbiota-Dependent Metabolite Trimethylamine N-Oxide and Coronary Artery Calcium in the Coronary Artery Risk Development in Young Adults Study (CARDIA).  Meyer K

Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk.  Meyer K

Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S

Related News

Good Nutrition Goes Hand-in-Hand with Portion Control 

Good Nutrition Goes Hand-in-Hand with Portion Control 

Have you been making changes to your nutrition intake in hopes of seeing a change on the scale, but you are not seeing what you expected? It could be that you’re under- or over-estimating how much you are eating.   While most people don’t weigh and measure their food,...

Protected: LISTEN Study

Password Protected

To view this protected post, enter the password below:

Wellness Workshop Wrap-Up

Wellness Workshop Wrap-Up

January marks a fresh start in many ways, including how to manage our own health. To help those who want a little guidance, the NRI recently presented a Wellness Workshop by partnering with High Performance Training, a privately owned gym in Kannapolis. Nutrition...

Free Event: Speed Dating with the NRI

Free Event: Speed Dating with the NRI

Speed Dating with the NRI: 3-minute Nutrition Theories Rowan Cabarrus Community College | Kannapolis, NC February 8, 2024 at 6 PM This year we’re doing this popular event again! Principal investigators, postdocs, doctoral students, and research specialists will take...

‘Human’ touch improves weight-management apps

‘Human’ touch improves weight-management apps

This article originally appeared on unc.edu. Written by Scott Jared, University Communications Traditional in-person weight-management programs result in about 10% weight loss over six to 12 months, better results than people get using more convenient smartphone apps....