Microbiome and Nutrition

The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.

Publications

 

Microbiome and Nutrition Publications

2020

Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K

2019

Association of dietary patterns with the gut microbiota in older, community-dwelling men.  Meyer K

The impact of early-life sub-therapeutic antibiotic treatment (STAT) on excessive weight is robust despite transfer of intestinal microbes.  Sumner S

Protein Intake at Twice the RDA in Older Men Increases Circulatory Concentrations of the Microbiome Metabolite Trimethylamine-N-Oxide (TMAO).  Zeisel S

2018

Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative.  Meyer K

Human microbiota, blood group antigens, and disease.  Sumner S

2017

Dietary Choline and Betaine and Risk of CVD: A Systematic Review and Meta-Analysis of Prospective Studies.  Meyer K

A Microbiomic Analysis in African Americans with Colonic Lesions Reveals Streptococcus sp.VT162 as a Marker of Neoplastic Transformation.  Sumner S

Metabolic profiling of a chronic kidney disease cohort reveals metabolic phenotype more likely to benefit from a probiotic.  Sumner S

Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease.  Zeisel S

2016

Microbiota-Dependent Metabolite Trimethylamine N-Oxide and Coronary Artery Calcium in the Coronary Artery Risk Development in Young Adults Study (CARDIA).  Meyer K

Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk.  Meyer K

Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S

Related News

Appetite for Life SoundBites Summer 2013

In this issue:
First comprehensive nutrigenetics book published
2013 Appetite for Life highlights
Art contest and N.C. Science Festival
Faculty News and Meet the People Behind the Science: Jody Albright, Research Asst.
Additions to Our Team
Student-led IMPACT Program

Catawba College Transfers Scientific Instruments to NRI

When Catawba College transferred state-of-the-art instrumentation to the NRI, it opened the door to expanding research capabilities for NRI scientists and real-life lab experience for Catawba students. The NRI will use the equipment to further its research into how metabolism and nutrition requirements are individualized.

Helping the world get healthier, one person at the time

May 31, 2013 – Researchers at the NRI are studying nutrition in a new way, discovering how diet and exercise affect health and help prevent chronic disease. Strengthened associations between individualized nutrition and enhanced health will have a global impact.

Dr. Philip May awarded $5.3M grant to study FASD

The National Institute of Health’s National Institute on Alcohol Abuse and Alcoholism awarded NRI Research Scientist Philip May, Ph.D. a $5.3 million grant to study Fetal Alcohol Spectrum Disorders in South Africa .

Dr. Martin Kohlmeier honored with Weinsier Award

Martin Kohlmeier, M.D., Ph.D., faculty member at the NRI, received the 2013 Roland L. Weinsier Award for Excellence in Medical/Dental Nutrition Education from the American Society for Nutrition (ASN).

NRI Director receives prestigious Greenberg Award

Stephen H. Zeisel, M.D., Ph.D., Kenan Distinguished University Professor in Nutrition and Pediatrics and UNC NRI Director, was the 2012 recipient of the Bernard G. Greenberg Alumni Endowment Award from the UNC Gillings School of Public Health. Dr. Zeisel was recognized for excellence in service to the public health community.