Microbiome and Nutrition
The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.
Publications
Microbiome and Nutrition Publications
2020
Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K
2019
Association of dietary patterns with the gut microbiota in older, community-dwelling men. Meyer K
2018
Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative. Meyer K
Human microbiota, blood group antigens, and disease. Sumner S
2017
Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease. Zeisel S
2016
Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk. Meyer K
Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S
Related News
Herman Freeman III
Research Technician, Sumner LabMr. Freeman joined the NRI as a research technician in the Sumner Lab in October 2019. He is learning the foundations of, and expanding his knowledge of, metabolomics research and how it is applied in fields today. He works...
Effect of Egg Ingestion on trimethylamine-N-oxide Production in Humans: A Randomized, Controlled, Dose-Response Study
Carolyn A Miller 1, Karen D Corbin 1, Kerry-Ann da Costa 1, Shucha Zhang 1, Xueqing Zhao 1, Joseph A Galanko 1, Tondra Blevins 1, Brian J Bennett 1, Annalouise O’Connor 1, Steven H Zeisel 1
Microbiota-Dependent Metabolite Trimethylamine N-Oxide and Coronary Artery Calcium in the Coronary Artery Risk Development in Young Adults Study (CARDIA)
Katie A Meyer 1, Thomas Z Benton 2, Brian J Bennett 3, David R Jacobs Jr 4, Donald M Lloyd-Jones 5, Myron D Gross 6, J Jeffrey Carr 7, Penny Gordon-Larsen 8, Steven H Zeisel 9
Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease
Steven H Zeisel 1, Manya Warrier 1
Protein Intake at Twice the RDA in Older Men Increases Circulatory Concentrations of the Microbiome Metabolite Trimethylamine-N-Oxide (TMAO).
Mitchell SM1, Milan AM2,3, Mitchell CJ4,5, Gillies NA6, D’Souza RF7,8, Zeng N9, Ramzan F10, Sharma P11, Knowles SO12, Roy NC13,14,15, Sjödin A16, Wagner KH17, Zeisel SH18, Cameron-Smith D19,20,21.
Melissa Shaffer
Social/Clinical Research Assistant, Cheatham Lab Melissa Shaffer joined the Nutrition Research Institute in January of 2020 as a research assistant in Dr. Cheatham’s Nutrition and Cognition Lab. In 2015 she graduated with a bachelor’s degree in Psychology from Bryan...