Microbiome and Nutrition

The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.

Publications

 

Microbiome and Nutrition Publications

2020

Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K

2019

Association of dietary patterns with the gut microbiota in older, community-dwelling men.  Meyer K

The impact of early-life sub-therapeutic antibiotic treatment (STAT) on excessive weight is robust despite transfer of intestinal microbes.  Sumner S

Protein Intake at Twice the RDA in Older Men Increases Circulatory Concentrations of the Microbiome Metabolite Trimethylamine-N-Oxide (TMAO).  Zeisel S

2018

Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative.  Meyer K

Human microbiota, blood group antigens, and disease.  Sumner S

2017

Dietary Choline and Betaine and Risk of CVD: A Systematic Review and Meta-Analysis of Prospective Studies.  Meyer K

A Microbiomic Analysis in African Americans with Colonic Lesions Reveals Streptococcus sp.VT162 as a Marker of Neoplastic Transformation.  Sumner S

Metabolic profiling of a chronic kidney disease cohort reveals metabolic phenotype more likely to benefit from a probiotic.  Sumner S

Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease.  Zeisel S

2016

Microbiota-Dependent Metabolite Trimethylamine N-Oxide and Coronary Artery Calcium in the Coronary Artery Risk Development in Young Adults Study (CARDIA).  Meyer K

Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk.  Meyer K

Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S

Related News

Early-Life Predictors of Fetal Alcohol Spectrum Disorders

Early-Life Predictors of Fetal Alcohol Spectrum Disorders

January 22, 2020 – The clinical teams at the UNC Nutrition Research Institute and in South Africa led by principal investigator Philip A. May, PhD have published findings of a decade-long effort to drive down the age at which the diagnosis of fetal alcohol spectrum disorders (FASD) can be made in affected children. The paper, “Early-Life Predictors of Fetal Alcohol Spectrum Disorders” is published in Pediatrics.

January 2020

NRI Congratulates First-time First-authors December 2019 –Agatha Christie once said, “The first time you do a thing is always exciting.” Well, we’ve had a lot of excitement at the Nutrition Research Institute recently! Two members of the Smith Lab are celebrating...

AFL Program Summaries September 2019 – May 2020

Appetite For Life – Wednesday, September 18, 2019: “Good Bowls: A social venture to improve healthy food access” was presented by Alice Ammerman, DrPH, Mildred Kaufman Distinguished Professor of Nutrition, Gillings School of Global Public Health, and Director of the...

Important NIH Award for NRI and Partners

Important NIH Award for NRI and Partners

December 12, 2019 – Agatha Christie once said, “the first time you do a thing is always exciting.” Well, we’ve had a lot of excitement at the Nutrition Research Institute recently! Two members of the Smith Lab are celebrating becoming first-time first-authors of scientific journal publications.

NRI Congratulates First-time First-Authors

NRI Congratulates First-time First-Authors

December 12, 2019 – Agatha Christie once said, “the first time you do a thing is always exciting.” Well, we’ve had a lot of excitement at the Nutrition Research Institute recently! Two members of the Smith Lab are celebrating becoming first-time first-authors of scientific journal publications.