Environment and Nutrition
Beginning at conception, environmental factors in health can accumulate over a lifetime and be from sources as broad as geographic location and economic status to specific external sources including physical activity, occupation, risky behaviors and diet. But some of these factors, especially in terms of diet are highly modifiable.
Important research is now being conducted on this concept of the “exposome,” as an environmental complement to the human genome. NRI researchers are learning how diet and other environmental exposures interact with disease and affect responses to treatment.
Publications
Environment and Nutrition Publications
2020
Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity. Zeisel S
Perspective: Dietary Biomarkers of Intake and Exposure-Exploration with Omics Approaches. Zeisel S
2019
Obesity and Cancer Metabolism: A Perspective on Interacting Tumor-Intrinsic and Extrinsic Factors. Hursting S
When less may be more: calorie restriction and response to cancer therapy. Hursting S
Energy balance and obesity: what are the main drivers? Hursting S
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Early-Life Predictors of Fetal Alcohol Spectrum Disorders. May P
Alcohol’s Dysregulation of Maternal-Fetal IL-6 and p-STAT3 Is a Function of Maternal Iron Status. Smith S
2018
Energy balance and gastrointestinal cancer: risk, interventions, outcomes and mechanisms. Hursting S
Research Strategies for Nutritional and Physical Activity Epidemiology and Cancer Prevention. Hursting S
2017
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Contribution of Dietary Supplements to Nutritional Adequacy in Various Adult Age Groups. Zeisel S
2016
CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress. Krupenko N
Abnormal Eating Behaviors Are Common in Children with Fetal Alcohol Spectrum Disorder. Smith S
Impact of a western diet on the ovarian and serum metabolome. Sumner S
Metabolomics enables precision medicine: “A White Paper, Community Perspective”. Sumner S
Related News
Importance of Ratio in Essential Fatty Acids
March 1, 2017 • While omega-3 fatty acid deficiencies have been clearly linked to memory and learning problems in rodent models, studies involving dietary supplementation have produced mixed results. A contributing factor could be that the ratio of omega-3 and omega-6 fatty acids in the diet is a more important marker than omega-3 fatty acid intake alone. This hypothesis is based on the fact that these fatty acids share metabolic pathways, and on the assumption that […]
Children’s Health Study
The purpose of this study is to identify genes and lifestyle factors that affect children’s health status and overall well-being.
February 2017
Breast Cancer Subtype Important in Deciding Impact of Folate It is generally known that folate (vitamin B9) is important in early pregnancy to prevent neural tube defects in babies, because folate is needed by rapidly dividing cells (e.g., those of a developing...
Breast Cancer Subtype Important in Deciding Impact of Folate
February 1, 2017 • It is generally known that folate (vitamin B9) is important in early pregnancy to prevent neural tube defects in babies, because folate is needed by rapidly dividing cells (e.g., those of a developing embryo) for DNA synthesis and cellular energy production. As a consequence, many processed foods in the United States are fortified with […]
One Scientist's 40-Year Journey to the First NIH-Endorsed FASD Diagnostic Criteria
January 1, 2017 • After almost 40 years of research, Philip May, PhD, a leading expert in the field of fetal alcohol spectrum disorders (FASD), and his team have published their fifth study on FASD in a South African community. Equally as monumental is the recent endorsement by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), one of the National Institutes of Health (NIH), of the FASD diagnostic guidelines that were developed by May’s research team […]
January 2017
What We're Learning about Mom's Nutrition and Alcohol Dr. Phil May’s research group at the NRI studies the prevalence of Fetal Alcohol Spectrum Disorders (FASD) in humans. The recent addition to the NRI faculty of Dr. Susan Smith now provides an avenue toward...