Genes and Nutrition
Each of us is metabolically unique. Gene variations known as SNPs (single nucleotide polymorphisms) often are a factor in an individual’s ability to metabolize or use nutrients efficiently. Each of our specific nutrient needs is affected by which specific combination of SNPs we have, but with thousands known to impact nutrition metabolism, how do we know what those needs are?
NRI researchers are working to create a “catalog” of SNPs that alter our nutritional needs by understanding how genetic and other complex biological information can be used to better estimate individual nutrition requirements and intolerances. Our scientists use bioinformatics to extract such information from population and intervention studies, develop rules for predicting individual needs, and bring precision nutrition to health care providers and consumers with digital tools.
Publications
Genes and Nutrition Publications
2020
Genetic variants affecting bone mineral density and bone mineral content at multiple skeletal sites in Hispanic children. Voruganti VS
Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity. Zeisel S
2019
DNA methylation in mice is influenced by genetics as well as sex and life experience. French J
Cytosolic 10-formyltetrahydrofolate dehydrogenase regulates glycine metabolism in mouse liver. Krupenko S
Deleterious mutations in ALDH1L2 suggest a novel cause for neuro-ichthyotic syndrome. Krupenko S
Fine mapping and identification of serum urate loci in American Indians: The Strong Heart Family Study. Voruganti VS
Heterogeneity in Metabolic Responses to Dietary Fructose. Voruganti VS
Genetic analysis of hsCRP in American Indians: The Strong Heart Family Study. Voruganti VS
A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity. Voruganti VS
Healthy dietary patterns and risk and survival of breast cancer: a meta-analysis of cohort studies. Voruganti VS
Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10-Pulmonary Function Association. Voruganti VS
2018
C16-ceramide is a natural regulatory ligand of p53 in cellular stress response. Krupenko N
Nutritional Genomics of Cardiovascular Disease. Voruganti VS
Genetic determinants of BMI from early childhood to adolescence: the Santiago Longitudinal Study. Voruganti VS
Serum Lipid Concentrations and FADS Genetic Variants in Young Mexican College Students: The UP-AMIGOS Cohort Study. Voruganti VS
Arsenic-gene interactions and beta-cell function in the Strong Heart Family Study. Voruganti VS
Dietary Modulation of the Epigenome. Zeisel S
2017
Exome sequencing reveals novel genetic loci influencing obesity-related traits in Hispanic children. Voruganti VS
Genetic variation underlying renal uric acid excretion in Hispanic children: the Viva La Familia Study. Voruganti VS
Reduced brain volume and impaired memory in betaine homocysteine S-methyltransferase knockout mice. Zeisel S
Choline, Other Methyl-Donors and Epigenetics. Zeisel S
2016
CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress. Krupenko N
Genotype, B-vitamin status, and androgens affect spaceflight-induced ophthalmic changes. Zeisel S
Related News
July 2015
July 2015 SoundBites features: The “-omics” of Nutrient Metabolism, Research We’re Reading: Go with Your Gut, Summer Tours and Fall Events
The Longevity Diet
https://www.youtube.com/watch?v=pLTJQEROMtA&feature=youtu.be
August 2015
August 2015 SoundBites features: Healthy Eyes at Every Age, Last Chance to Tour the NRI, and Cooking for Nourishment: Demo + Talk
Healthy Eyes at Every Age
July 22, 2015 • Speakers at the recent Institute of Food Technologists meeting in Chicago in July discussed an essential nutrient that plays a vital role in human health. Unfortunately, few people have heard of it and fewer still are eating enough of it.
“Choline is an essential but widely under-consumed nutrient,” says Catherine Adams Hutt, registered dietician and science and nutrition advisor to The Choline Information Council®. “Only children typically get enough choline and most adults, including pregnant and lactating women, don’t get as much choline as they need. Just as choline is essential in the development of the brain, it is also critical for the development of the mechanics of our eyes,” she adds.
The “-omics” of Nutrient Metabolism
July 1, 2015 • How our bodies use the nutrients that nourish us drives much of the science at the Nutrition Research Institute. Recent advances in nutrition studies have shed light on the metabolic fates of nutrients and about the molecular actors and mechanisms responsible for the underlying processes. A major reason for the explosive advances in the understanding of nutrient metabolism has been the massive investigative use of all kinds of “-omics,” new fields of study for the mining of data-rich biological information.
Go With Your Gut: How a community of trillions affects your individual health
July 1, 2015 • Everyday we learn more about how the gut microbiome may influence health. Our gut microbial community—a super-organism, with trillions of members—has been associated with obesity, diabetes, cancer, heart disease, and immune disorders, and even moods. These findings have generated enormous enthusiasm among researchers and the lay public, as they suggest a largely untapped area for health-promoting interventions. One mechanism through which the gut microbiome may affect health is through the metabolism of food and nutrients.