Microbiome and Nutrition

The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.

Publications

 

Microbiome and Nutrition Publications

2020

Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K

2019

Association of dietary patterns with the gut microbiota in older, community-dwelling men.  Meyer K

The impact of early-life sub-therapeutic antibiotic treatment (STAT) on excessive weight is robust despite transfer of intestinal microbes.  Sumner S

Protein Intake at Twice the RDA in Older Men Increases Circulatory Concentrations of the Microbiome Metabolite Trimethylamine-N-Oxide (TMAO).  Zeisel S

2018

Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative.  Meyer K

Human microbiota, blood group antigens, and disease.  Sumner S

2017

Dietary Choline and Betaine and Risk of CVD: A Systematic Review and Meta-Analysis of Prospective Studies.  Meyer K

A Microbiomic Analysis in African Americans with Colonic Lesions Reveals Streptococcus sp.VT162 as a Marker of Neoplastic Transformation.  Sumner S

Metabolic profiling of a chronic kidney disease cohort reveals metabolic phenotype more likely to benefit from a probiotic.  Sumner S

Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease.  Zeisel S

2016

Microbiota-Dependent Metabolite Trimethylamine N-Oxide and Coronary Artery Calcium in the Coronary Artery Risk Development in Young Adults Study (CARDIA).  Meyer K

Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk.  Meyer K

Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S

Related News

A Paper on Sodium

by Grayson Burgess The NRI’s fourth annual Virtual Internship Program (VIP) concluded on July 20 with 21 high school students from around the country presenting their research on the nutrients of their choice. Their research papers have been compiled into a journal,...

Folate is Essential, But Don’t Overdo It

Folate is a water-soluble vitamin, naturally found in many foods. Folate helps to make DNA and RNA and is involved in metabolism of amino acids. It is needed to produce healthy red blood cells and plays a key role in removing homocysteine, a molecule that can exert...

Purchase a Brick

Pave the Way to a Healthier Future To purchase a commemorative brick, complete the form below. Upon hitting submit, you will be directed to the payment page. A 4″x8″ brick is $125. If you would like to buy more than one brick please revisit this page and place another...

A Paper on Choline

by Sumayyah Elkhouly The NRI’s fourth annual Virtual Internship Program (VIP) concluded on July 20 with 21 high school students from around the country presenting their research on the nutrients of their choice. Their research papers have been compiled into a journal,...

VIP Student Journal: 2023

Our Virtual Internship Program is offered to high school students (those entering 9th grade through recent graduates entering their freshman year of college in the fall of 2023. This four-week program provides opportunities to learn from NRI principal investigators, participate in group mentoring sessions, and complete an independent nutrition research paper and presentation.