Microbiome and Nutrition
The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.
Publications
Microbiome and Nutrition Publications
2020
Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K
2019
Association of dietary patterns with the gut microbiota in older, community-dwelling men. Meyer K
2018
Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative. Meyer K
Human microbiota, blood group antigens, and disease. Sumner S
2017
Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease. Zeisel S
2016
Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk. Meyer K
Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S
Related News
Preventing Fetal Alcohol Spectrum Disorders (FASD)
November 24, 2015 • From the desk of: David Horita, Ph.D.
THE STUDY
In a recently published paper1, NRI investigator Phil May and colleagues showed that the prevalence of fetal alcohol syndrome (FAS) and partial fetal alcohol syndrome (PFAS) is two to three times higher than previously estimated.
Dr. May’s study differs from most FAS prevalence studies in its use of active case ascertainment testing methods to estimate prevalence. This technique includes developmental testing of the child and detailed one-on-one interviews of the mother. The interview questions covered alcohol use during pregnancy, but also asked questions related to secondary factors, such as overall drinking history, marital status; socioeconomic status, and diet/nutrition. This approach is much more labor-intensive than the more common survey approach that relies on self-reported alcohol use information. However, it is also more accurate: self-reported alcohol usage surveys often underestimate FAS because of the stigma of drinking during pregnancy.
Healthy Brain Function Tied to Nutrition
November 24, 2015 • The research in Dr. Carol L. Cheatham’s Nutrition and Cognition lab focuses on effects of nutrition on brain development and function throughout the lifespan. In her work, she is exploring the importance of certain nutrients and foods to the development, maintenance, and lifelong integrity of the hippocampus and frontal brain areas. Nutrition is integral to fetal and infant brain development, which sets the stage for lifelong learning. At the other end of the spectrum, it is beginning to be evident that nutrition is also important in senescence in that certain nutrients coupled with other healthy lifestyle choices can slow the progression of age-related cognitive decline. Dr. Cheatham has active studies in four age groups; some of that work is summarized here.
NRI Researcher Receives Award to Further Work on Obesity and Cancer
December 1, 2015 • University of North Carolina (UNC) at Chapel Hill professor Stephen Hursting has received a prestigious National Cancer Institute (NCI) Outstanding Investigator Award (OIA), which provides stable funding for cancer research with breakthrough potential. Dr. Hursting, a professor in UNC’s Department of Nutrition, Nutrition Research Institute and Lineberger Comprehensive Cancer Center, is one of 43 researchers nationwide to receive an OIA. The grant will provide Hursting with $5.34 million over a seven-year period to further his research on the mechanistic links between obesity and cancer.
Dr. Hursting Awarded Grant from Breast Cancer Research Foundation
October 28, 2015 • The Breast Cancer Research Foundation seeks “to prevent and cure breast cancer by advancing the world’s most promising research.”Since 1993 BCRF-supported investigators have been deeply involved in every major advance in breast cancer prevention, diagnosis and treatment. In 2015-2016, BCRF is awarding $48.5 million in grants to more than 240 scientists to advance this work. Among those recipients is Stephen Hursting, Ph.D., M.P.H., Professor of Nutrition at the UNC Nutrition Research Institute.
Is Life Expectancy a Good Measure of Health?
October 27, 2015 • A recent, global study published in The Lancet (2015; 386, p.743-800) clearly emphasizes the importance of the latter referring to our quality of life. According to the Global Burden of Disease (GBD) study, worldwide life expectancy at birth rose by 6.2 years between 1990 and 2013. However, these additional years come at a price as healthy life expectancy at birth increased by only 5.4 years over the same 13 year time span.
Arugula, Mozzarella and Black Grapes
October 27, 2015 • Arugula, Mozzarella and Black Grapes recipe designed by Chef Mark Allison, Dole Food Company.