Microbiome and Nutrition
The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.
Publications
Microbiome and Nutrition Publications
2020
Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K
2019
Association of dietary patterns with the gut microbiota in older, community-dwelling men. Meyer K
2018
Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative. Meyer K
Human microbiota, blood group antigens, and disease. Sumner S
2017
Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease. Zeisel S
2016
Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk. Meyer K
Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S
Related News
Mom’s Diet Can Affect Development of Next Two Generations
November 17, 2016 • Nutritional deficiencies during pregnancy can have lasting effects across generations that impact development not only of children, but also of grandchildren. These heritable effects are linked to epigenetic changes that affect gene expression but not DNA sequence. At the NRI, we seek to understand how nutrition affects health and why different people respond differently to the same nutrients.
Nutrition Research Institute Shows Choline is Essential to a Normal Diet
November 1, 2016 • Though it’s present in a variety of foods and an essential part of a person’s diet, many people may not have heard of the nutrient choline.
Researchers from the University of North Carolina at Chapel Hill’s Nutrition Research Institute, located at the NC Research Campus in Kannapolis, have studied the impact that diets lacking in choline could have on everything from liver and muscle tissue to brain development.
November 2015
November 1, 2015 • In this edition of our monthly e-news learn why researchers say no drinking when pregnant, is life expectancy a good measure of health and congratulate Dr. Hursting on his latest award.
November 2016
Do Eggs Cause Heart Disease? Several recent studies linked increased levels of a metabolic product of dietary choline with higher risk of cardiovascular disease (CVD) (Wang et al., 2011; Tang et al., 2013) through a mechanism that involved gut microbiota-produced...
Do Eggs Cause Heart Disease?
October 25, 2016 • Several recent studies linked increased levels of a metabolic product of dietary choline with higher risk of cardiovascular disease (CVD) (Wang et al., 2011; Tang et al., 2013) through a mechanism that involved gut microbiota-produced trimethylamine oxide (TMAO). These studies have sparked considerable scientific (and non-scientific) discussion, with health advice from some groups suggesting avoidance of meat and eggs (significant sources of choline) and from others suggesting that the findings have been vastly overinterpreted.
Sugar-Sweetened Beverages Increase Risk for Hyperuricemia
October 25, 2016 • According to the CDC, sugar-sweetened beverages are the largest source of added sugar in the average American’s diet, and the Dietary Guidelines for Americans recommend individuals consume no more than ten percent of calories per day from processed or added sugar. From the UNC Chapel Hill Nutrition Research Institute (NRI), scientists are investigating the connection between these beverages, human genetics, and uric acid metabolism.