Microbiome and Nutrition
The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.
Publications
Microbiome and Nutrition Publications
2020
Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K
2019
Association of dietary patterns with the gut microbiota in older, community-dwelling men. Meyer K
2018
Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative. Meyer K
Human microbiota, blood group antigens, and disease. Sumner S
2017
Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease. Zeisel S
2016
Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk. Meyer K
Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S
Related News
Local Research Institute Boosts Economy through Critical Nutrition Discoveries
March 17, 2015 • Eleven faculty research scientists at the UNC Nutrition Research Institute (NRI) in Kannapolis currently have externally funded grants to support their work exploring individualized nutrition. These awards are significant not only for providing the means by which the NRI can advance its scientific discoveries but also for their economic impact in the Charlotte region. Continue Reading Local Research Institute Boosts Economy through Critical Nutrition Discoveries
Research campus moving past slow start, looking to define future
March 8, 2015 • The following has been reprinted from The Salisbury Post, an article by Josh Bergeron.
The N.C. Research Campus still lags behind initial employment projections, but, as the nation and state recover from an economic recession, growth is beginning to pick up.
Following billionaire businessman David Murdock’s $15 million annual endowment last year, the research campus aims to expand and the David H. Murdock Research Institution is looking to refocus on its initial intent — becoming a world class research institution. The catchphrase being used to define the future of the facility is “putting the RI back in DHMRI.” Continue Reading Research campus moving past slow start, looking to define future
Understanding Nutrigenomics
March 2, 2015 • Why “good” and “bad” are irrelevant when talking about genes and nutrition
From the desk of: Mihai Niculescu, M.D., Ph.D.
…“How to override your bad genes with food.” “Can Exercise Override Bad Genes?” “Good Nutrition Can Overcome Bad Genes”…
woman drawing dnaWe are bombarded by media with these kinds of messages. The main theme, of course, is that many of us may have “bad” genes that would put us at risk of a certain poor health outcome unless we eat less of “this” and more of “that.” Knowing myself as a bearer of several such genetic variations, I almost feel, at times, guilty that I am harboring such “bad” genes, albeit without my consent. Continue Reading Understanding Nutrigenomics
NRI Scientist Achieves New Role
March 2, 2015 • Natalia Surzenko, Ph.D., studies the connections between nutrients and brain and eye development. Her work in this area has been as Research Scientist in the Zeisel lab since joining the NRI in 2013. In recognition of the excellence she brings to her research, Dr. Surzenko has been promoted to Research Assistant Professor. Continue Reading NRI Scientist Achieves New Role
March 2015
Free Public Presentation Registration Required–Sign Up Today The NRI's popular public event series, Appetite for Life, continues on Tuesday, March 10 with a free presentation by Patrick Stover, Ph.D., on Keeping a Hungry World Healthy: Our Changing Food...
Series to help laypeople understand science
Saturday, February 14, 2015 • The following has been reprinted from Charlotte Observer, an article by Lisa Thornton. If Dr. Natalia Surzenko told you that choline produces increased hippocampal neurogenesis in Mus musculus, you probably wouldn’t understand. But if she said a nutrient called choline, naturally found in foods such as egg yolks, salmon and cocoa powder has been shown to regenerate brain cells responsible for increased memory in mice, that would be different. At the UNC Nutrition Research Institute in Kannapolis, where Surzenko, a neurobiologist, has her lab, a new series called “Appetite for Life” is intended to create clearer dialogue between researchers and laypeople about discoveries changing the way experts view nutrition. Continue Reading Series to help laypeople understand science
