Microbiome and Nutrition

The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.

Publications

 

Microbiome and Nutrition Publications

2020

Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K

2019

Association of dietary patterns with the gut microbiota in older, community-dwelling men.  Meyer K

The impact of early-life sub-therapeutic antibiotic treatment (STAT) on excessive weight is robust despite transfer of intestinal microbes.  Sumner S

Protein Intake at Twice the RDA in Older Men Increases Circulatory Concentrations of the Microbiome Metabolite Trimethylamine-N-Oxide (TMAO).  Zeisel S

2018

Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative.  Meyer K

Human microbiota, blood group antigens, and disease.  Sumner S

2017

Dietary Choline and Betaine and Risk of CVD: A Systematic Review and Meta-Analysis of Prospective Studies.  Meyer K

A Microbiomic Analysis in African Americans with Colonic Lesions Reveals Streptococcus sp.VT162 as a Marker of Neoplastic Transformation.  Sumner S

Metabolic profiling of a chronic kidney disease cohort reveals metabolic phenotype more likely to benefit from a probiotic.  Sumner S

Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease.  Zeisel S

2016

Microbiota-Dependent Metabolite Trimethylamine N-Oxide and Coronary Artery Calcium in the Coronary Artery Risk Development in Young Adults Study (CARDIA).  Meyer K

Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk.  Meyer K

Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S

Related News

AFL Program Summaries 2020

Appetite For Life – Thursday, January 16, 2020: “Genes and individual response to nutrients in bone health,” was presented by Saroja Voruganti, PhD, Associate Professor of Nutrition, UNC Nutrition Research Institute. Studies have shown that obesity and diabetes weaken...

AFL Program Summaries 2019

Appetite For Life – Wednesday, January 16, 2019 with Yuan Li, PhD, Postdoctoral Research Associate-Sumner Lab: “Traditional Medicine: From Grandma’s Observations to Evidence-based Science” The long-standing system of medical treatment in China, especially the use of...

AFL Program Summaries 2017

Appetite For Life – September 27, 2017, with Folami Ideraabdullah, PhD: “Vitamin D and Human Health: 10 Things Your Mother Never Told You”. Vitamin D is an essential vitamin linked to human health and diseases such as cancer, diabetes, and heart disease. It occurs...

2018 Appetite for Life

Appetite For Life – Monday, January 22, 2018, with Carol Cheatham, PhD, Associate Professor of Psychology and Neuroscience: “Why do we eat applesauce with pork?” Many explanations can be found as to why certain foods are always eaten together; some actually make...

Understanding and Managing Stress Eating

Understanding and Managing Stress Eating

by Irene Wang Originally published by the Living F.R.E.E. Lab During stressful times, many people reach for something crunchy, salty, or sweet - food that’s easily accessible and full of flavor, even when hunger isn’t the reason. While this is a common response, it’s...