News
Our research not only influences the scientific community, but the general public as well. We strive to share our discoveries with everyone. Read some of our latest articles on what is happening at the Nutrition Research Institute.
Choline Metabolism Provides Novel Insights into Non-Alcoholic Fatty Liver Disease and its Progression
Corbin, KD, Zeisel, SH. (2012) Choline Metabolism Provides Novel Insights into Non-alcoholic Fatty Liver Disease and its Progression. Curr Opin Gastroenterol. 28:159-165. PMID:22134222
Protein Kinase Cα Phosphorylates a Novel Argininosuccinate Synthase Site at Serine 328 during Calcium-dependent Stimulation of Endothelial Nitric-oxide Synthase in Vascular Endothelial Cells
Haines, RJ, Corbin, KD, Pendleton, LC, Eichler, DE. (2012) PKCα Phosphorylates a Novel Argininosuccinate Synthase Site at S328 During Calcium-Dependent Stimulation of eNOS in Vascular Endothelial Cells. J Biol Chem. 287: 26168–26176. PMID:22696221
Insulin transcriptionally regulates argininosuccinate synthase to maintain vascular endothelial function
Haines, RJ, Corbin, KD, Pendleton, LC, Meininger, CJ Eichler, DE. (2012) Insulin transcriptionally regulates argininosuccinate synthase to maintain vascular endothelial function. Biochem Biophys Res Commun. 421:9-14.
Choline Dehydrogenase Polymorphism RS12676 is a Functional Variation and is Associated with Changes in Human Sperm Cell Function
Johnson, A.R., Lao, S., Wang, T., Galanko, J.A., Zeisel, S.H. (2012) Choline dehydrogenase polymorphism rs12676 is a functional variation and is associated with changes in human sperm cell function. PLoS ONE. 7(4): e36047. PMID: 22558321.
Perinatal Epigenetic Determinants of Cognitive and Metabolic Disorders
Lupu DS and Niculescu MD (2012) Perinatal Epigenetic Determinants of Cognitive and Metabolic Disorders. Aging and Disease 3
Maternal-linolenicacid availability during gestation and lactation alters the postnatal hippocampal Development in the Mouse Offspring
Niculescu MD, Lupu, DS and Craciunescu CN (2012) Perinatal manipulation of α-linolenic acid intake induces epigenetic changes in maternal and offspring livers. The FASEB Journal 27
Choline Intake and Risk of Lethal Prostate Cancer Incidence and Survival
Richman, E.L., Kenfield, S.A., Stampfer, M.J., Giovannucci, E.L., Zeisel, S.H., Willett, W.C., Chan, J.M. (2012) Choline intake and risk of lethal prostate cancer: incidence and survival. American Journal of Clinical Nutrition. 96(4): 855 – 863. PMID: 22952174.
p38 Mitogen-activated Protein Kinase (MAPK) PromotesCholesterol Ester Accumulation in Macrophages through Inhibition of Macroautophag
Shuang Mei, Haihua Gu, Adam Ward, Xuefeng Yang, Huailan Guo, Ka He, Zhenqi Liu, and Wenhong Cao (2012) p38 Mitogen-activated Protein Kinase (MAPK) Promotes Cholesterol Ester Accumulation in Macrophages through Inhibition of Macroautophagy THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 287, NO. 15, pp. 11761–11768
Mouse Betaine-Homocysteine S-Methyltransferase deficiency reduces body fat via increasing energy expenditure and impairing lipid synthesis and enhancing glucose oxidation in white adipose tissue
Teng, Y-W, Ellis, J.M., Coleman, R.A., Zeisel, S.H. (2012) Mouse Betaine-Homocysteine S-Methyltransferase deficiency reduces body fat via increasing energy expenditure and impairing lipid synthesis and enhancing glucose oxidation in white adipose tissue. e. Journal of Biological Chemistry. 287(20): 16187 – 98. PMID: 22362777.