News
Our research not only influences the scientific community, but the general public as well. We strive to share our discoveries with everyone. Read some of our latest articles on what is happening at the Nutrition Research Institute.
Effects of Inadequate Hydration on Kidney Disease
December 21, 2015 • While drinking at least eight glasses of water a day may not be necessary under normal conditions, maintaining adequate hydration, especially during physical exertion in warm weather, is essential for optimal health.
ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate
“ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate”. Keenan MM, Liu B, Tang X, Jianli Wu J, Cyr D, Robert D, RD, Olga Ilkayeva O, Huang Z, Susan K. Murphy SK, Joseph Lucas J, Deborah M. Muoio DM, Kim SY Jen-Tsan Chi JT (2015). PLoS Genet, 11(10).
Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis
“Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis”. Tang X, Keenan MM, Wu J, Lin CA, Dubois L, Thompson JW, Freedland SJ, Murphy SK, Chi JT (2015). PLoS Genet. 11(4).
Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress
“Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress”. LaMonte GM, Tang X, Chen LY, Wu J, Ding CK, Keenan MM, Sangokoya C, Kung HN, Ilkayeva O, Boros LG, Newgard CB and Chi JT (2013). Cancer & Metabolism, 1(1): 23.
A joint analysis of metabolomics and genetics of breast cancer
“A joint analysis of metabolomics and genetics of breast cancer”. Tang X, Lin CC, Spasojevic I, Iversen ES, Chi JT, Marks JR (2014). Breast Cancer Res. 16(4): 415.
A high-throughput screening method for small molecule inhibitors of the aberrant mutant SOD1 and Dynein interaction
“A high-throughput screening method for small molecule inhibitors of the aberrant mutant SOD1 and Dynein interaction”. Tang X, Seyb KI, Huang M, Schuman ER, Shi P, Zhu Z, Glicksman MA (2012). Journal of Biomolecular Screen (3): 314-26.
Functional interaction between responses to lactic acidosis and hypoxia regulates genomic transcriptional outputs
“Functional interaction between responses to lactic acidosis and hypoxia regulates genomic transcriptional outputs”. Tang X, Joseph Lucas JE, Ling-Yu J. Chen JL, LaMonte G, Wu J, Wang MC, Costantinos Koumenis Chi JT (2012). Cancer Research, 72(2): 491-502.
December 2014
Appetite for Life Public Programing Mark Your Calendar The Nutrition Research Institute's popular series of public programs, called Appetite for Life, resumes this January for a five-month run. Once each month, January through May, distinguished science researchers...
Preventing Fetal Alcohol Spectrum Disorders (FASD)
November 24, 2015 • From the desk of: David Horita, Ph.D.
THE STUDY
In a recently published paper1, NRI investigator Phil May and colleagues showed that the prevalence of fetal alcohol syndrome (FAS) and partial fetal alcohol syndrome (PFAS) is two to three times higher than previously estimated.
Dr. May’s study differs from most FAS prevalence studies in its use of active case ascertainment testing methods to estimate prevalence. This technique includes developmental testing of the child and detailed one-on-one interviews of the mother. The interview questions covered alcohol use during pregnancy, but also asked questions related to secondary factors, such as overall drinking history, marital status; socioeconomic status, and diet/nutrition. This approach is much more labor-intensive than the more common survey approach that relies on self-reported alcohol use information. However, it is also more accurate: self-reported alcohol usage surveys often underestimate FAS because of the stigma of drinking during pregnancy.