Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort.
Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups.
Genetic Signatures in Choline and 1-Carbon Metabolism
Corbin, K. D., Abdelmalek, M. F., Spencer, M. D., da Costa, K. A., Galanko, J. A., Sha, W., Suzuki, A., Guy, C. D., Cardona, D. M., Torquati, A., Diehl, A. M., and Zeisel, S. H. (2013) Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis. FASEB J 27, 1674-1689
Aberrant estrogen regulation of PEMT results in choline deficiency-associated liver dysfunction.
Dietary Choline Requirements of Women Effects of Estrogen and Genetic Variation
Fischer, L.M., da Costa, K-A, Kwock, L., Galanko, J., Zeisel, S.H. (2010) Dietary choline requirements of women: effects of estrogen and genetic variation. American Journal of Clinical Nutrition. 92(5):1113-19. PMCID: PMC2954445.
Choline Intake and Genetic Polymorphisms Influence Choline Metabolite Concentrations in Human Breast Milk and Plasma
Fischer, L.M., daCosta, K-A, Galanko, J., Sha, W., Stephenson, B., Vick, J., Zeisel, S.H. (2010) Choline intake and genetic polymorphisms influence choline metabolite concentrations in human breast milk and plasma. American Journal of Clinical Nutrition. 92(2): 336-346. PMCID: PMC2904035.