George Flentke, PhD

George Flentke received his Ph.D. in Biochemistry from the University of Wisconsin-Madison, where his dissertation focused on the structure and catalytic activity of the enzyme UDP-galactose-4-epimerase,  which is crucial for galactose metabolism. His postdoctoral research in Biochemistry and Pharmacology at Tufts University / New England Medical School focused on the design of inhibitors of dipeptidyl peptidase enzymes, which control immune function and HIV infection.  After returning to UW-Madison he continued working with the immunosupressives cyclosporine and rapamycin. He is an experienced enzymologist/protein chemist and synthetic organic chemist. Currently, he manages Dr. Smith’s lab, where he investigates the mechanism by which alcohol alters ribosomal signaling and mTOR activity in alcohol-exposed neural crest.