High-throughput transcriptome sequencing identifies candidate genetic modifiers of vulnerability to fetal alcohol spectrum disorders.
Preventing Fetal Alcohol Spectrum Disorders (FASD)
November 24, 2015 • From the desk of: David Horita, Ph.D.
THE STUDY
In a recently published paper1, NRI investigator Phil May and colleagues showed that the prevalence of fetal alcohol syndrome (FAS) and partial fetal alcohol syndrome (PFAS) is two to three times higher than previously estimated.
Dr. May’s study differs from most FAS prevalence studies in its use of active case ascertainment testing methods to estimate prevalence. This technique includes developmental testing of the child and detailed one-on-one interviews of the mother. The interview questions covered alcohol use during pregnancy, but also asked questions related to secondary factors, such as overall drinking history, marital status; socioeconomic status, and diet/nutrition. This approach is much more labor-intensive than the more common survey approach that relies on self-reported alcohol use information. However, it is also more accurate: self-reported alcohol usage surveys often underestimate FAS because of the stigma of drinking during pregnancy.
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Hoeferlin LA, Oleinik NV, Krupenko NI, Krupenko SA.
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PMID: 22593801
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Rho GTPases RhoA and Rac1 mediate effects of dietary folate on metastatic potential of A549 cancer cells through the control of cofilin phosphorylation.
Oleinik NV, Helke KL, Kistner-Griffin E, Krupenko NI, Krupenko SA.
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Strickland KC, Krupenko NI, Krupenko SA.
Clin Chem Lab Med. 2013 Mar 1;51(3):607-16. doi: 10.1515/cclm-2012-0561. Review.
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