Environment and Nutrition
Beginning at conception, environmental factors in health can accumulate over a lifetime and be from sources as broad as geographic location and economic status to specific external sources including physical activity, occupation, risky behaviors and diet. But some of these factors, especially in terms of diet are highly modifiable.
Important research is now being conducted on this concept of the “exposome,” as an environmental complement to the human genome. NRI researchers are learning how diet and other environmental exposures interact with disease and affect responses to treatment.
Publications
Environment and Nutrition Publications
2020
Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity. Zeisel S
Perspective: Dietary Biomarkers of Intake and Exposure-Exploration with Omics Approaches. Zeisel S
2019
Obesity and Cancer Metabolism: A Perspective on Interacting Tumor-Intrinsic and Extrinsic Factors. Hursting S
When less may be more: calorie restriction and response to cancer therapy. Hursting S
Energy balance and obesity: what are the main drivers? Hursting S
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Early-Life Predictors of Fetal Alcohol Spectrum Disorders. May P
Alcohol’s Dysregulation of Maternal-Fetal IL-6 and p-STAT3 Is a Function of Maternal Iron Status. Smith S
2018
Energy balance and gastrointestinal cancer: risk, interventions, outcomes and mechanisms. Hursting S
Research Strategies for Nutritional and Physical Activity Epidemiology and Cancer Prevention. Hursting S
2017
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Contribution of Dietary Supplements to Nutritional Adequacy in Various Adult Age Groups. Zeisel S
2016
CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress. Krupenko N
Abnormal Eating Behaviors Are Common in Children with Fetal Alcohol Spectrum Disorder. Smith S
Impact of a western diet on the ovarian and serum metabolome. Sumner S
Metabolomics enables precision medicine: “A White Paper, Community Perspective”. Sumner S
Related News
One Size Won’t Fit All
August 20, 2019 – Nearly 35 percent of Americans are considered obese — a diagnosis that has become so common the American Medical Association recognizes it as a chronic disease. While the diagnosis is the same for all, the treatments vary; what works for one person typically doesn’t work for another. In response, researchers from across UNC have joined forces to tackle this ever-growing problem.
August 2019
Startup SNP Therapeutics Merges Gene Testing With Personalized Nutrition July 15 2019 – In what may be the ultimate affirmation of “you are what you eat,” an innovative Charlotte-area company is merging high-tech genomic testing with personalized nutritional...
Hops Study
Study Purpose: To evaluate the effects of hops, a naturally occurring product, in the regulation of blood sugars. Recruiting: 18-70 year old males and females who do not smoke and are generally in good health What participants will do: Participants will volunteer for...
Meeting Areas & Office Space
The NRI building was designed with collaboration, collegiality and productivity in mind. Meeting areas and office space adjoin or connect the different clinical and laboratory research areas throughout the building. In addition to the 32,500 square feet of wet space...
On-campus Resources
The NRI’s location on the NCRC puts our scientists only footsteps away from the David H. Murdock Research Institute (DHMRI) which offers some of the best biotechnology equipment available, including a molecular genomics laboratory, a metabolomics laboratory, a 950 MHz...
Wet Laboratories
The NRI provides state-of-the-art laboratories with modern equipment for experiments that require 1) pyrosequencing to conduct quantitative genetic analyses; 2) gene sequencing and gene expression analyses; and 3) genomic and bacterial DNA purification. Labs are...