Susan J. Sumner, PhD

Professor of Nutrition and Pharmacology

Susan Sumner, PhD is a Professor of Nutrition at UNC Chapel Hill’s Nutrition Research Institute (NRI), and the Director of the Metabolomics and Exposome Laboratory (MEL) at UNC Chapel Hill. Dr. Sumner is working to make personalized medicine and precision nutrition a reality.  Using state-of-the-art metabolomics and exposome technologies, Dr. Sumner’s team determines how molecules that are present in our tissues and biological fluids are associated with states of health and wellness. Through this approach, biomarkers are discovered that can lead to new diagnostics for the early detection and diagnosis of disease, to monitor treatment and intervention, and to inform the development of intervention strategies.

The Sumner-Lab uses analytical methods to detect tens of thousands of signals for molecules that are present in biological specimens (such as urine, serum, plasma, feces, sweat, tissues, and cells).Using untargeted metabolomics/exposome analysis, signals are detected for metabolites that are derived from endogenous metabolic process, such as neurotransmitters, hormones and steroids, sugars, amino acids, purines and pyrimidines, lipids, fatty acids, and vitamins and essential nutrients. Signals are also detected for metabolites derived from a wide range of exposures, including metabolites derived from ingestion of foods, intake of medications or drugs of abuse, and environmentally relevant chemicals.

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Natural occurring chemicals found in foods (e.g., folate, choline) and beverages (e.g., polyphenols, benzoate) have been associated with both positive and negative health responses. Perturbations in endogenous metabolism have been associated with many prescription and over the counter medications, as well as illicit drugs. Metabolites of many environmentally relevant chemicals are also detected (including  phthalates, pesticides, polycyclic aromatic hydrocarbons, parabens, brominated flame retardants, tobacco products, phenols, and volatile organic compounds) which have been linked with a variety of adverse health outcomes – including obesity, cognitive delay and decline, reproductive effects, and cancer.

Dr. Sumner’s research activities in Personalized Medicine and Precision Nutrition span several domain areas of Maternal and Child Health, Diabetes and Kidney Disease, Toxicology, Cancer, Microbiome, and Addiction. In 2019, she received a grant from the National Heart Lung and Blood Institute (NHLBI) to discover biomarkers and mechanisms associated with Cardiovascular Disease. She has served as the PI of a grant funded through the National Institute of General Medical Sciences (NIGMS) to use metabolomics to reveal noninvasive markers of drug-induced liver injury, and as PI of the NIH Common Fund Eastern Regional Comprehensive Metabolomics Resource Core (ERCMRC). She previously directed the Metabolomics Core for the UNC Chapel Hill Nutrition Obesity Resource Center (NORC, funded by the National Institute of Diabetes and Digestive and Kidney Diseases, NIDDK), and an Exposome Core for the Children’s Health Exposure Analysis Resource (CHEAR) program (funded by the National Institutes of Environmental Health Sciences, NIEHS).

In August of 2019, Dr. Sumner received a grant to develop new tools and conduct untargeted analysis for the NIEHS-funded Human Health Exposure Analysis Resource (HHEAR) Program. Under this grant, untargeted analysis is used to study the complex interactions between environmental exposures throughout the lifespan and human health outcomes in the HHEAR and the Environmental Influences on Childhood Outcomes programs. In 2022, her team received an award from NCI as the NIH Common Fund Metabolomics and Clinical Assay Center as part of the NIH Nutrition for Precision Health Consortium powered by All of Us. In this role, her Center will help develop algorithms that predict individual’s responses to dietary intake. 

Dr. Sumner earned a B.S. and Ph.D. in the Department of Chemistry at North Carolina State University, and conducted postdoctoral research at NHLBI.

Sumner’s Team

Emily Brasseur : Research Technician, Sumner Lab

Emily Brasseur

Research Technician, Sumner Lab

Emily graduated from Catawba College with a Bachelors in Biochemistry and a minor in History in 2023. She is excited to be with the Sumner Lab and looks forward to learning everything that she can. She is a Michigan native that misses the snow but does not miss the cold. In her down time, Emily loves to read, play games, and crochet many different things.

ebrass@unc.edu
Mansi Choudhari : Student Research Assistant, Sumner Lab

Mansi Choudhari

Student Research Assistant, Sumner Lab

Mansi Choudhari is a Summer intern at the Sumner Lab. She is a BSPH Nutrition student at the UNC Gillings School of Global Public Health. She is also pursuing a minor in Medicine, Literature, and Culture. She is interested in preventative medicine and looks forward to learning from the NRI team. In her free time, she enjoys trying new recipes and spending time with friends.

mansi29@unc.edu
Bryan Chuprinko, MBA : Visiting Scholar, Sumner Lab

Bryan Chuprinko, MBA

Visiting Scholar, Sumner Lab

Bryan Chuprinko is a Program Manager at Coddle Creek Capital, overseeing life science programs. He has collaborated with UNC-NRI on behalf of Coddle Creek Capital to bring value to the North Carolina Research Campus (NCRC).

bryan@coddlecapital.com
Rachel Coble, MS : Assistant Laboratory Manager, Sumner Lab

Rachel Coble, MS

Assistant Laboratory Manager, Sumner Lab

Rachel Joined the UNC Chapel Hill NRI in August 2020 as a Research Technician in the Sumner Lab. As a local of Rowan County, specifically China Grove, she graduated from Catawba College in 2020 with a B.S. in Biochemistry. She has always wanted to have some kind of involvement at the NCRC ever since she saw the campus being built as a little girl. Since joining Sumner’s lab, Coble returned to school to further her education. Pursuing her Master's degree in Informatics and Analytics with a Bioinformatics concentration has been a transformative journey, significantly enhancing her expertise in handling and interpreting complex data sets. By learning analytical techniques and informatics tools, she is equipped to process vast amounts of metabolomic data with greater accuracy and efficiency. The skills and knowledge gained through her Master's program enable her to contribute more to her metabolomics research, drive impactful data-driven insights, and support the NRI's goals in advancing metabolomics.

rachel_coble@unc.edu
Isabella Falcone : Student Research Assistant, Sumner Lab

Isabella Falcone

Student Research Assistant, Sumner Lab

Isabella joined the Sumner Lab as a student intern in 2023. She is an undergraduate student pursuing a BSPH in the Nutrition program through the UNC Gillings School of Global Public Health, as well as a minor in Chemistry. As Isabella aims to attend medical school following her undergraduate career, she is eager to learn from Dr. Sumner and her team. In Isabella’s free time she enjoys running, baking, and crafting

ifalcone@ad.unc.edu
Grace Fu, BSPH : Graduate Assistant, Sumner Lab

Grace Fu, BSPH

Graduate Assistant, Sumner Lab

Grace joined NRI and began her MS program in June 2024. She graduated from UNC Chapel Hill in May 2024 with a BSPH in Nutrition and minors in Chemistry and Studio Art. Her research involves integrating multi-omics data to compare individuals with healthy lifestyles versus unhealthy lifestyles and looking for associations with cancer. She wishes to use the knowledge she gains this year in her future medical career. Outside of academics, Grace enjoys reading, discussing her faith, and playing volleyball, basketball, and guitar.

huiyufu@email.unc.edu
Susan McRitchie, MA, MS : Program Manager, Sumner Lab

Susan McRitchie, MA, MS

Program Manager, Sumner Lab

Susan McRitchie, MA/MS has over 10 years of experience conducting biostatistics in the field of metabolomics, and has over 15 years of experience using biostatistics in clinical and epidemiology investigations. She is the lead biostatistician and program manager for the NIH Common Fund Metabolomics and Clinical Assay Center (PI, Susan Sumner) for the Nutrition for Precision Health study, for the NIEHS Human Health Exposure Analysis Resource program (MPI, Sumner/Du/Fennell), and for the Metabolomics and Exposome Laboratory at the UNC Chapel Hill Nutrition Research Institute (Director, Sumner). In these roles, she participates in working groups of the NIH consortium involving data management, data quality, and omics analysis, and leads data analysis. She has trained over 20 students, postdoctoral fellows, early career and senior faculty to conduct statistical and multivariate analysis in metabolomics investigations. Susan McRitchie earned a MA in mathematics from UCLA and a MS in Biostatistics from UNC Chapel Hill.

susan_mcritchie@unc.edu
Sabrina Molina : Assistant Laboratory Manager, Sumner Lab

Sabrina Molina

Assistant Laboratory Manager, Sumner Lab

Sabrina graduated from UNC Charlotte with a degree in biology, working in a bioinformatics lab during her time there. She began as a student intern in the Sumner lab and is now working as the Assistant Laboratory Manager. She is very excited to continue working with all the amazing people at the NRI. In her spare time, Sabrina enjoys cooking, kayaking, fishing, and dirt biking.

sabrina_molina@unc.edu
Wimal Pathmasiri, PhD : Assistant Professor of Nutrition

Wimal Pathmasiri, PhD

Assistant Professor of Nutrition

Wimal Pathmasiri, PhD  is an Assistant Professor at the University of North Carolina at Chapel Hill’s Nutrition Research Institute (NRI).  An overarching goal of Dr. Pathmasiri’ s research includes understanding the links between exposures (diet, constituents in natural projects, environmental chemicals, drugs), microbial metabolism, and human health. He was worked with the Sumner-Lab for over 12 years, as the director of a technology core for the NIH Common Fund Eastern Regional Comprehensive Metabolomics Resource Core (ERCMRC), and as a co-investigator in the North Carolina Human Health Exposure Analysis Resource Untargeted Analysis Laboratory (NC HHEAR UAL). Learn more.

wimal_pathmasiri@unc.edu
Blake Rushing, PhD : Assistant Professor of Nutrition

Blake Rushing, PhD

Assistant Professor of Nutrition

Blake Rushing, PhD, is an assistant professor of nutrition at the University of North Carolina at Chapel Hill’s Nutrition Research Institute (NRI). Dr. Rushing’s is trained in pharmacology and toxicology, and has experience using liquid chromatography-mass spectrometry, nuclear magnetic resonance, in vitro model systems, and various biochemical assays to study the interactions between small molecule toxins/drugs with macromolecular targets such as proteins and DNA. He is well versed in using analytical instrumentation to study metabolic products of exogenous small molecule agents and their biological effects. Learn more.

blake_rushing@unc.edu
Braden Yorke : Student Research Assistant, Sumner Lab

Braden Yorke

Student Research Assistant, Sumner Lab

Braden Yorke is an undergraduate student at the University of North Carolina at Chapel Hill, pursuing a degree in Nutrition Science and Research. Braden is an intern in Dr. Sumner’s lab at the UNC Nutrition Research Institute where he hopes to explore the field and learn as much as possible.

blyorke@ad.unc.edu

BSPH Students

Heidi Cao

Heidi Cao

BSPH Candidate

Mansi Choudhari

Mansi Choudhari

BSPH Candidate

The North Carolina Human Health Exposure Analysis Resource Hub (NC HHEAR Hub)

Metabolomics and Exposome Laboratory (MEL) for the following NIH Centers

Nutritional Pharmacology/Toxicology

Choline and Related Metabolites in Nutrition Research

Metabolomics: Using In Vitro Models to Reveal Mechanisms of Cellular Response

700 MHz NMR Spectroscopy Services on the North Carolina Research Campus

Quantitative Targeted Analysis of Host Metabolism - Biocrates

Recent Grants

R01CA282657 (Rushing, PI, UNC-CH): 2024 – 2029
NIH/NCI
The Human Cancer Metabolome Atlas

 1U24CA268153-02S (Sumner, PI, UNC-CH):2023 – 2025
NCI/NIH Common Fund
Nutrition for Precision Health: Targeted Metabolomics, Phytochemicals, and Clinical Assays 

1U24CA268153 (Sumner, PI, UNC-CH): 2022 – 2027
NCI/NIH Common Fund
Metabolomics and Clinical Assays Center (MCAC) for the Nutrition for the Precision Health Study

1R01DK126666-01 (Sumner, MPI, UNC-CH):2021 – 2026
NIDDK
Mechanistic and metabolic underpinnings of ALDH1L1 polymorphisms in the regulation of glycine metabolism

1U2CES030857 (Sumner, MPI, UNC-CH):2019 – 2026
NIEHS
Human Health Exposure Analysis Resource (HHEAR) Hub and Environmental Influences on Childhood Outcomes (ECHO)

U01OH011300-05 (Nolan, PI, NYUSOM): 2017 – 06/30/2026
NIOSH
Title:  Metabolomics of World Trade Center-Lung Injury

R01HL143885 (Sumner, MPI, UNC-CH): 2019–2023
NHLBI
Leveraging multi-omics approaches to examine metabolic challenges of obesity in relation to cardiovascular diseases.

1U01CA235507 (Du, PI, UNC-Charlotte): 2018–2022
NCI
Cross-Platform and Graphical Software Tool for Adaptive LC/MS and GC/MS Metabolomics Data Preprocessing

1R37CA226969-01 (Bae-Jump, PI, UNC-CH): 2018–2023
NCI
Obesity-driven Metabolic and Molecular Biomarkers of Metformin Response in Endometrial Cancer

1R21CA235029-01 (Smith-Ryan & Bae-Jump, MPI, UNC Chapel Hill): 2019–2020
NCI
Interval Exercise Training as a Therapy for Endometrial Cancer

1U01OH011300-01A1 (Nolan, PI, NYUSOM): 2017– 2023
NIOSH
Metabolomics of World Trade Center-Lung Injury

1R01DK115380-01 (Zeisel, PI, UNC Chapel Hill): 2017- 2021
NIDDK
Developing a Biomarker Panel to Assess Choline Nutritional Status

U01ES027254 (Sumner, MPI, UNC Chapel Hill): 2016–2021  
National Institute of Environmental Health Sciences
Early-life END exposure and the impact on neurobehavioral, cardiovascular, and biochemical mechanisms.

5UG3OD023275 (Karagas, PI, Dartmouth College): 2016-2023
National Institute of Environmental Health Sciences
Environmental Influences of Child Health Outcomes (ECHO) Pediatrics Cohort
New Hampshire Birth Cohort

5UG3OD023305 (Trasande, PI, NYU School of Medicine): 2016-2023
National Institute of Environmental Health Sciences
Environmental Influences of Child Health Outcomes (ECHO) Pediatrics Cohort
NYU Pediatric Obesity, Metabolism and Kidney Cohort Center 

R01DK110077 (Smoyer, PI, Nationwide Children’s Hospital)   2017-2022
NIDDK
Integrating Proteomics and Metabolomics to Understand Pediatric Glomerular Disease

1R21HD087878-01A1 (Harville, PI, Tulane): 2017-2019
NICHD
Preterm birth, pre-eclampsia, and the exposome

In the News

Q & A with Grace Fu

Q & A with Grace Fu

My research project: Multi-omics signatures of Healthy vs Unhealthy Lifestyles, and Association with Cancer Related Biomarkers 1. What drew you to pursue the UNC Nutrition Research Institute (NRI)? I want to gain more nutritional knowledge before starting medical...

Breast cancer risks and new treatment options

Breast cancer risks and new treatment options

The combination of few treatment options and the aggressive nature of triple-negative breast cancer (TNBC) results in a higher recurrence and mortality rate. Research from the NRI seeks to understand TNBC mechanisms with the goal of directing development of...

Precision nutrition improves health at individual level, expert says

Precision nutrition improves health at individual level, expert says

Susan Sumner, PhD, is a professor of Nutrition and pharmacology at the UNC Nutrition Research Institute. Using state-of-the-art metabolomics and exposome technologies, Sumner’s team determines how molecules that are present in our tissues and biological fluids are...

Publications

2021 Publications

2021

Emerging technologies and their impact on regulatory science

Chemical exposures assessed via silicone wristbands and endogenous plasma metabolomics during pregnancy

Fecal Metabolomics Reveals Products of Dysregulated Proteolysis and Altered Microbial Metabolism in Obesity-Related Osteoarthritis

Association of Cesarean Delivery and Formula Supplementation with the Stool Metabolome of 6-week-old Infants

Intravenous Administration of Three Multi-Walled Carbon Nanotubes to Female Rats and their Effect on Urinary Biochemical Profile

The Effects of Diet and Exercise on Endogenous Estrogens and Subsequent Breast Cancer Risk in Postmenopausal Women

Bridging the Gap Between Analytical and Microbial Sciences in Microbiome Research

Associations between the gut microbiome and metabolome in early life

Association of Increased Serum Lipopolysaccharide but not Microbial Dysbiosis with Obesity-related Osteoarthritis

Knockout of putative tumor suppressor Aldh1l1 in mice reprograms metabolism to accelerate growth of tumors in a diethylnitrosamine (DEN) model of liver carcinogenesis

Simulated Gastric Digestion and In Vivo Intestinal Uptake of Orally Administered CuO Nanoparticles and TiOE171 in Male and Female Rat Pups

Multi-omics analysis of glucose-mediated signaling by a moonlighting Gβ protein Asc1/RACK1

Metabolic Response of Triple-Negative Breast Cancer to Folate Restriction

Information enhanced model selection for Gaussian graphical model with application to metabolomic data

The role of gut microbial community and metabolomic shifts in adaptive resistance of Atlantic killifish (Fundulus heteroclitus) to polycyclic aromatic hydrocarbons

Untargeted analysis of first trimester serum to reveal biomarkers of pregnancy complications: a case-control discovery phase study

Metabolomics reveals biomarkers of opioid use disorder

Existing antiviral options against SARS-CoV-2 replication in COVID-19 patients

2019 Publications

Predicting and Defining Steroid Resistance in Pediatric Nephrotic Syndrome Using Plasma Metabolomics.

Predicting and Defining Steroid Resistance in Pediatric Nephrotic Syndrome Using Plasma Proteomics.

Cytosolic 10-formyltetrahydrofolate dehydrogenase regulates glycine metabolism in mouse liver.

Multi-omics studies in cellular models of methylmalonic acidemia and propionic acidemia reveal dysregulation of serine metabolism.

LC-MS-based metabolomics analysis to identify meprin-β-associated changes in kidney tissue from mice with STZ-induced type 1 diabetes and diabetic kidney injury.

Deleterious mutations in ALDH1L2 suggest a novel cause for neuro-ichthyotic syndrome.

Meprin β metalloproteases associated with differential metabolite profiles in the plasma and urine of mice with type 1 diabetes and diabetic nephropathy.

Health-related quality of life in glomerular disease.

A metabolomics approach to investigate kukoamine B – a potent natural product with anti-diabetic properties.

The impact of early-life sub-therapeutic antibiotic treatment (STAT) on excessive weight is robust despite transfer of intestinal microbes.

Human PAH is characterized by a pattern of lipid-related insulin resistance.

CureGN Study Rationale, Design, and Methods: Establishing a Large Prospective Observational Study of Glomerular Disease.

Metabolomics for Biomarker Discovery and to Derive Genetics Links to Disease.

Exposure to inorganic arsenic and its methylated metabolites alters metabolomics profiles in INS-1 832/13 insulinoma cells and isolated pancreatic islets.

Quantitative methods for metabolic analyses evaluated in the Children’s Health Exposure Analysis Resource (CHEAR).

Metabolomics to reveal biomarkers and pathways of preterm birth: A systematic review and epidemiologic perspective.

 

2017 Publications

A Microbiomic Analysis in African Americans with Colonic Lesions Reveals Streptococcus sp.VT162 as a Marker of Neoplastic Transformation.

Detailed Investigation and Comparison of the XCMS and MZmine 2 Chromatogram Construction and Chromatographic Peak Detection Methods for Preprocessing Mass Spectrometry Metabolomics Data.

One Step Forward for Reducing False Positive and False Negative Compound Identifications from Mass Spectrometry Metabolomics Data: New Algorithms for Constructing Extracted Ion Chromatograms and Detecting Chromatographic Peaks.

Metabolomics reveal physiological changes in mayfly larvae (Neocloeon triangulifer) at ecological upper thermal limits.

Pretreatment with indomethacin results in increased heat stroke severity during recovery in a rodent model of heat stroke.

Direct and transgenerational effects of low doses of perinatal di-(2-ethylhexyl) phthalate (DEHP) on social behaviors in mice.

Metabolites as biomarkers of adverse reactions following vaccination: A pilot study using nuclear magnetic resonance metabolomics.

Metabolic profiling of a chronic kidney disease cohort reveals metabolic phenotype more likely to benefit from a probiotic.

Neonatal Metabolomic Profiles Related to Prenatal Arsenic Exposure.

Systems biology for organotypic cell cultures.

Serum Metabolomic Profiles in Neonatal Mice following Oral Brominated Flame Retardant Exposures to Hexabromocyclododecane (HBCD) Alpha, Gamma, and Commercial Mixture.

Disposition of intravenously or orally administered silver nanoparticles in pregnant rats and the effect on the biochemical profile in urine.

Preterm neonatal urinary renal developmental and acute kidney injury metabolomic profiling: an exploratory study.