Wimal Pathmasiri, PhD

Assistant Professor of Nutrition, Sumner Lab

Wimal Pathmasiri, PhD is an Assistant Professor at the University of North Carolina at Chapel Hill’s Nutrition Research Institute (NRI).  An overarching goal of Dr. Pathmasiri’ s research includes understanding the links between exposures (diet, constituents in natural projects, environmental chemicals, drugs), microbial metabolism, and human health. He was worked with the Sumner-Lab for over 12 years, as the director of a technology core for the NIH Common Fund Eastern Regional Comprehensive Metabolomics Resource Core (ERCMRC), and as a co-investigator in the North Carolina Human Health Exposure Analysis Resource Untargeted Analysis Laboratory (NC HHEAR UAL). Dr. Pathmasiri develops and applies metabolomics to reveal metabolic pathway perturbations associated with disease states, therapeutic treatments, and environmentally relevant exposures. He has contributed to research in the areas of cancer, childhood obesity, early-life exposure to antibiotics, environmental exposure, kidney disease, osteoarthritis, rare diseases, and toxicology. Dr. Pathmasiri earned a BSc and MPhil from the University of Colombo, Sri Lanka, and a Licentiate of Philosophy from the Uppsala University, Sweden. He earned a PhD in Chemistry from Uppsala University and conducted postdoctoral research at UNC Chapel Hill, and at RTI International.

Collaboration Team

Susan J. Sumner, PhD

Susan J. Sumner, PhD

Professor of Nutrition

susan_sumner@unc.edu
704-250-5066

Delisha Stewart, PhD

Delisha Stewart, PhD

Assistant Professor of Nutrition, Sumner Lab

delisha_stewart@unc.edu
704-250-5068

Publications

2020

Analysis of NMR Metabolomics Data.

Quantitative methods for metabolomic analyses evaluated in the Children’s Health Exposure Analysis Resource (CHEAR).

 

2019

A Metabolomics Approach to Investigate Kukoamine B-A Potent Natural Product With Anti-diabetic Properties.

The impact of early-life sub-therapeutic antibiotic treatment (STAT) on excessive weight is robust despite transfer of intestinal microbes.

 

2018

Stable Isotope-Resolved Metabolomic Differences between Hormone-Responsive and Triple-Negative Breast Cancer Cell Lines.

Plasma metabolomics analysis in sickle cell disease patients with albuminuria – an exploratory study.

Antibiotic-induced acceleration of type 1 diabetes alters maturation of innate intestinal immunity.

Correlated metabolomic, genomic, and histologic phenotypes in histologically normal breast tissue.

 

2017

A Microbiomic Analysis in African Americans with Colonic Lesions Reveals Streptococcus sp.VT162 as a Marker of Neoplastic Transformation.

Effect of endotoxin and alum adjuvant vaccine on peanut allergy.

Metabolomics reveal physiological changes in mayfly larvae (Neocloeon triangulifer) at ecological upper thermal limits.

Pretreatment with indomethacin results in increased heat stroke severity during recovery in a rodent model of heat stroke.

Disposition of intravenously or orally administered silver nanoparticles in pregnant rats and the effect on the biochemical profile in urine.

Metabolites as biomarkers of adverse reactions following vaccination: A pilot study using nuclear magnetic resonance metabolomics.

Neonatal Metabolomic Profiles Related to Prenatal Arsenic Exposure.

Natural Compounds as Occult Ototoxins? Ginkgo biloba Flavonoids Moderately Damage Lateral Line Hair Cells.

Serum Metabolomic Profiles in Neonatal Mice following Oral Brominated Flame Retardant Exposures to Hexabromocyclododecane (HBCD) Alpha, Gamma, and Commercial Mixture.

Preterm neonatal urinary renal developmental and acute kidney injury metabolomic profiling: an exploratory study.

 

2016

Training in metabolomics research. II. Processing and statistical analysis of metabolomics data, metabolite identification, pathway analysis, applications of metabolomics and its future.

A General Method for Targeted Quantitative Cross-Linking Mass Spectrometry.

Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice.

Impact of a western diet on the ovarian and serum metabolome.

Metabolomics Analysis of Hormone-Responsive and Triple-Negative Breast Cancer Cell Responses to Paclitaxel Identify Key Metabolic Differences.

Training in metabolomics research. I. Designing the experiment, collecting and extracting samples and generating metabolomics data.

Training in metabolomics research. I. Designing the experiment, collecting and extracting samples and generating metabolomics data.

Microfluidics meets metabolomics to reveal the impact of Campylobacter jejuni infection on biochemical pathways.

Metabolomics Reveals New Mechanisms for Pathogenesis in Barth Syndrome and Introduces Novel Roles for Cardiolipin in Cellular Function.

Association of urinary metabolites with radiographic progression of knee osteoarthritis in overweight and obese adults: an exploratory study.