Genes and Nutrition

Each of us is metabolically unique. Gene variations known as SNPs (single nucleotide polymorphisms) often are a factor in an individual’s ability to metabolize or use nutrients efficiently. Each of our specific nutrient needs is affected by which specific combination of SNPs we have, but with thousands known to impact nutrition metabolism, how do we know what those needs are?

NRI researchers are working to create a “catalog” of SNPs that alter our nutritional needs by understanding how genetic and other complex biological information can be used to better estimate individual nutrition requirements and intolerances. Our scientists use bioinformatics to extract such information from population and intervention studies, develop rules for predicting individual needs, and bring precision nutrition to health care providers and consumers with digital tools.

Publications

 

Genes and Nutrition Publications

2020

Genetic variants affecting bone mineral density and bone mineral content at multiple skeletal sites in Hispanic children.  Voruganti VS

Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity.  Zeisel S

2019

DNA methylation in mice is influenced by genetics as well as sex and life experience.  French J

Cytosolic 10-formyltetrahydrofolate dehydrogenase regulates glycine metabolism in mouse liver.  Krupenko S

Deleterious mutations in ALDH1L2 suggest a novel cause for neuro-ichthyotic syndrome.  Krupenko S

Fine mapping and identification of serum urate loci in American Indians: The Strong Heart Family Study.  Voruganti VS

Heterogeneity in Metabolic Responses to Dietary Fructose.  Voruganti VS

Genetic analysis of hsCRP in American Indians: The Strong Heart Family Study.  Voruganti VS

A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity.  Voruganti VS

Healthy dietary patterns and risk and survival of breast cancer: a meta-analysis of cohort studies.  Voruganti VS

Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10-Pulmonary Function Association.  Voruganti VS

Betaine-homocysteine S-methyltransferase deficiency causes increased susceptibility to noise-induced hearing loss associated with plasma hyperhomocysteinemia.  Zeisel S

MicroRNA-129-5p is regulated by choline availability and controls EGF receptor synthesis and neurogenesis in the cerebral cortex.  Zeisel S

2018

Introduction to mammalian genome special issue: the combined role of genetics and environment relevant to human disease outcomes.  French J

C16-ceramide is a natural regulatory ligand of p53 in cellular stress response.  Krupenko N

Metabolic Phenotype of Wild-Type and As3mt-Knockout C57BL/6J Mice Exposed to Inorganic Arsenic: The Role of Dietary Fat and Folate Intake.  Krupenko S

Nutritional Genomics of Cardiovascular Disease.  Voruganti VS

Genetic determinants of BMI from early childhood to adolescence: the Santiago Longitudinal Study.  Voruganti VS

Genetic Variants Related to Cardiometabolic Traits Are Associated to B Cell Function, Insulin Resistance, and Diabetes Among AmeriCan Indians: The Strong Heart Family Study.  Voruganti VS

Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function.  Voruganti VS

Serum Lipid Concentrations and FADS Genetic Variants in Young Mexican College Students: The UP-AMIGOS Cohort Study.  Voruganti VS

Arsenic-gene interactions and beta-cell function in the Strong Heart Family Study.  Voruganti VS

Dietary Modulation of the Epigenome.  Zeisel S

2017

NTP Research Report on Absence of Formaldehyde-Induced Neoplasia in Trp53 Haploinsufficient Mice Exposed by Inhalation: Research Report 3 [Internet].  French J

QTL Mapping and Identification of Candidate Genes in DO Mice: A Use Case Model Derived from a Benzene Toxicity Experiment.  French J

Heterogeneity of p53 dependent genomic responses following ethanol exposure in a developmental mouse model of fetal alcohol spectrum disorder.  Mooney S

Exome sequencing reveals novel genetic loci influencing obesity-related traits in Hispanic children.  Voruganti VS

Genetic variation underlying renal uric acid excretion in Hispanic children: the Viva La Familia Study.  Voruganti VS

Reduced brain volume and impaired memory in betaine homocysteine S-methyltransferase knockout mice.  Zeisel S

Betaine is accumulated via transient choline dehydrogenase activation during mouse oocyte meiotic maturation.  Zeisel S

Deletion of one allele of Mthfd1 (methylenetetrahydrofolate dehydrogenase 1) impairs learning in mice.  Zeisel S

Choline, Other Methyl-Donors and Epigenetics.  Zeisel S

Choline and its metabolites are differently associated with cardiometabolic risk factors, history of cardiovascular disease, and MRI-documented cerebrovascular disease in older adults.  Zeisel S

Altered methylation of specific DNA loci in the liver of Bhmt-null mice results in repression of Iqgap2 and F2rl2 and is associated with development of preneoplastic foci.  Zeisel S

2016

CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress.  Krupenko N

Genotype, B-vitamin status, and androgens affect spaceflight-induced ophthalmic changes.  Zeisel S

Related News

Pinpointing Individual Susceptibility for Heart Disease

March 31, 2015 • The following has been reprinted from NC Research Campus, transforming-science.com
Eat a healthy and balanced diet. That is the first advice that people who need to reduce their risk for cardiovascular disease (CVD) receive. But what if some nutrients in “healthy” foods interact with an individual’s genetic make-up in a way that actually increases their risk for CVD.
That is the question that Brian Bennett, PhD, is trying to answer. Bennett is an assistant professor of genetics, nutrition and heart disease with the UNC Chapel Hill Nutrition Research Institute (NRI) at the NC Research Campus in Kannapolis. He is pushing the boundaries of nutrigenomics, which is the study of how genes and diet interact, to reveal new clues about individual susceptibility for atherosclerosis and other forms of CVD.

April 2015

April 22 • April 2015’s edition of SoundBites features: The Folic Acid Dilemma, Appetite for Life Lecture, Liver Cancer Report Reveals New Links, Training Your Doctor in Nutrition, and 2015 ISNN Congress.

2015 ISNN Congress

March 30, 2015 • The International Society of Nutrigenetics and Nutrigenomics (ISNN) will hold its 9th Congress May 17-19 on the campus of UNC Chapel Hill. This event convenes several hundred nutrition researchers, clinicians, dietitians and other healthcare providers who are leaders in the development and practice of advanced nutrition solutions. Keynote speakers are 2007 Nobel laureate Dr. Oliver Smithies (UNC Chapel Hill) and Dr. Bruce Ames (Children’s Hospital Oakland Research Institute and UC Berkeley), who will deliver an Appetite for Life lecture in Kannapolis May 20, 2015.

Local Research Institute Boosts Economy through Critical Nutrition Discoveries

March 17, 2015 • Eleven faculty research scientists at the UNC Nutrition Research Institute (NRI) in Kannapolis currently have externally funded grants to support their work exploring individualized nutrition. These awards are significant not only for providing the means by which the NRI can advance its scientific discoveries but also for their economic impact in the Charlotte region.

Research campus moving past slow start, looking to define future

March 8, 2015 • The following has been reprinted from The Salisbury Post, an article by Josh Bergeron.
The N.C. Research Campus still lags behind initial employment projections, but, as the nation and state recover from an economic recession, growth is beginning to pick up.
Following billionaire businessman David Murdock’s $15 million annual endowment last year, the research campus aims to expand and the David H. Murdock Research Institution is looking to refocus on its initial intent — becoming a world class research institution. The catchphrase being used to define the future of the facility is “putting the RI back in DHMRI.”

Transcription factor Olig2 defines subpopulations of retinal progenitor cells biased toward specific cell fates

Transcription factor Olig2 defines subpopulations of retinal progenitor cells biased toward specific cell fates
Brian P. Hafler, Natalia Surzenko, Kevin T. Beier, Claudio Punzo, Jeffrey M. Trimarchi, Jennifer H. Kong, Constance L. Cepko
Proc Natl Acad Sci U S A. 2012 May 15; 109(20): 7882–7887. Published online 2012 April 27. doi: 10.1073/pnas.1203138109
PMCID: PMC3356608