Microbiome and Nutrition

The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.

Publications

 

Microbiome and Nutrition Publications

2020

Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K

2019

Association of dietary patterns with the gut microbiota in older, community-dwelling men.  Meyer K

The impact of early-life sub-therapeutic antibiotic treatment (STAT) on excessive weight is robust despite transfer of intestinal microbes.  Sumner S

Protein Intake at Twice the RDA in Older Men Increases Circulatory Concentrations of the Microbiome Metabolite Trimethylamine-N-Oxide (TMAO).  Zeisel S

2018

Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative.  Meyer K

Human microbiota, blood group antigens, and disease.  Sumner S

2017

Dietary Choline and Betaine and Risk of CVD: A Systematic Review and Meta-Analysis of Prospective Studies.  Meyer K

A Microbiomic Analysis in African Americans with Colonic Lesions Reveals Streptococcus sp.VT162 as a Marker of Neoplastic Transformation.  Sumner S

Metabolic profiling of a chronic kidney disease cohort reveals metabolic phenotype more likely to benefit from a probiotic.  Sumner S

Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease.  Zeisel S

2016

Microbiota-Dependent Metabolite Trimethylamine N-Oxide and Coronary Artery Calcium in the Coronary Artery Risk Development in Young Adults Study (CARDIA).  Meyer K

Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk.  Meyer K

Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S

Related News

Research Assistant – Tate Lab

The position is located in Kannapolis, NC, approximately 2 hours from UNC’s main campus. Position Summary Chapel Hill received funding to establish both a targeted Health Care Provider Organization (HPO) for the All of Us Research Program and a Clinical Center...

Winning at Weight Loss in the Tech Era with Deborah Tate, PhD

Winning at Weight Loss in the Tech Era with Deborah Tate, PhD

Originally aired on the Weight Loss And podcast In a world filled with smart rings, fitness trackers, and weight loss apps, knowing which digital tools actually work — and how to use them — can feel overwhelming. To help listeners cut through the noise, Weight Loss...

Celebrating a Career of Impact: Voruganti Named ASN Fellow

Celebrating a Career of Impact: Voruganti Named ASN Fellow

Saroja Voruganti, PhD, Director of the Clinical Research Core at the UNC Nutrition Research Institute (NRI), has been named one of the first recipients of the new Excellence in Nutrition "Fellow of ASN" (FASN) designation by the American Society for Nutrition (ASN)....

Postdoctoral Scholar – Rushing Lab

This position is located in Kannapolis, NC, approximately 2 hours from UNC’s main campus. Position Summary We are seeking a highly motivated individual with expertise in cancer cell biology, metabolism, and molecular biology techniques to join our team. The...