Microbiome and Nutrition
The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.
Publications
Microbiome and Nutrition Publications
2020
Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K
2019
Association of dietary patterns with the gut microbiota in older, community-dwelling men. Meyer K
2018
Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative. Meyer K
Human microbiota, blood group antigens, and disease. Sumner S
2017
Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease. Zeisel S
2016
Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk. Meyer K
Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S
Related News
Importance of Ratio in Essential Fatty Acids
March 1, 2017 • While omega-3 fatty acid deficiencies have been clearly linked to memory and learning problems in rodent models, studies involving dietary supplementation have produced mixed results. A contributing factor could be that the ratio of omega-3 and omega-6 fatty acids in the diet is a more important marker than omega-3 fatty acid intake alone. This hypothesis is based on the fact that these fatty acids share metabolic pathways, and on the assumption that […]
Children’s Health Study
The purpose of this study is to identify genes and lifestyle factors that affect children’s health status and overall well-being.
February 2017
Breast Cancer Subtype Important in Deciding Impact of Folate It is generally known that folate (vitamin B9) is important in early pregnancy to prevent neural tube defects in babies, because folate is needed by rapidly dividing cells (e.g., those of a developing...
Breast Cancer Subtype Important in Deciding Impact of Folate
February 1, 2017 • It is generally known that folate (vitamin B9) is important in early pregnancy to prevent neural tube defects in babies, because folate is needed by rapidly dividing cells (e.g., those of a developing embryo) for DNA synthesis and cellular energy production. As a consequence, many processed foods in the United States are fortified with […]
One Scientist's 40-Year Journey to the First NIH-Endorsed FASD Diagnostic Criteria
January 1, 2017 • After almost 40 years of research, Philip May, PhD, a leading expert in the field of fetal alcohol spectrum disorders (FASD), and his team have published their fifth study on FASD in a South African community. Equally as monumental is the recent endorsement by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), one of the National Institutes of Health (NIH), of the FASD diagnostic guidelines that were developed by May’s research team […]
January 2017
What We're Learning about Mom's Nutrition and Alcohol Dr. Phil May’s research group at the NRI studies the prevalence of Fetal Alcohol Spectrum Disorders (FASD) in humans. The recent addition to the NRI faculty of Dr. Susan Smith now provides an avenue toward...