Microbiome and Nutrition
The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.
Publications
Microbiome and Nutrition Publications
2020
Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K
2019
Association of dietary patterns with the gut microbiota in older, community-dwelling men. Meyer K
2018
Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative. Meyer K
Human microbiota, blood group antigens, and disease. Sumner S
2017
Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease. Zeisel S
2016
Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk. Meyer K
Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S
Related News
ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate
“ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate”. Keenan MM, Liu B, Tang X, Jianli Wu J, Cyr D, Robert D, RD, Olga Ilkayeva O, Huang Z, Susan K. Murphy SK, Joseph Lucas J, Deborah M. Muoio DM, Kim SY Jen-Tsan Chi JT (2015). PLoS Genet, 11(10).
Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis
“Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis”. Tang X, Keenan MM, Wu J, Lin CA, Dubois L, Thompson JW, Freedland SJ, Murphy SK, Chi JT (2015). PLoS Genet. 11(4).
Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress
“Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress”. LaMonte GM, Tang X, Chen LY, Wu J, Ding CK, Keenan MM, Sangokoya C, Kung HN, Ilkayeva O, Boros LG, Newgard CB and Chi JT (2013). Cancer & Metabolism, 1(1): 23.
A joint analysis of metabolomics and genetics of breast cancer
“A joint analysis of metabolomics and genetics of breast cancer”. Tang X, Lin CC, Spasojevic I, Iversen ES, Chi JT, Marks JR (2014). Breast Cancer Res. 16(4): 415.
A high-throughput screening method for small molecule inhibitors of the aberrant mutant SOD1 and Dynein interaction
“A high-throughput screening method for small molecule inhibitors of the aberrant mutant SOD1 and Dynein interaction”. Tang X, Seyb KI, Huang M, Schuman ER, Shi P, Zhu Z, Glicksman MA (2012). Journal of Biomolecular Screen (3): 314-26.
Functional interaction between responses to lactic acidosis and hypoxia regulates genomic transcriptional outputs
“Functional interaction between responses to lactic acidosis and hypoxia regulates genomic transcriptional outputs”. Tang X, Joseph Lucas JE, Ling-Yu J. Chen JL, LaMonte G, Wu J, Wang MC, Costantinos Koumenis Chi JT (2012). Cancer Research, 72(2): 491-502.