Microbiome and Nutrition
The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.
Publications
Microbiome and Nutrition Publications
2020
Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K
2019
Association of dietary patterns with the gut microbiota in older, community-dwelling men. Meyer K
2018
Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative. Meyer K
Human microbiota, blood group antigens, and disease. Sumner S
2017
Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease. Zeisel S
2016
Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk. Meyer K
Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S
Related News
NRI Scientist Achieves New Role
March 2, 2015 • Natalia Surzenko, Ph.D., studies the connections between nutrients and brain and eye development. Her work in this area has been as Research Scientist in the Zeisel lab since joining the NRI in 2013. In recognition of the excellence she brings to her research, Dr. Surzenko has been promoted to Research Assistant Professor.
March 2015
Free Public Presentation Registration Required–Sign Up Today The NRI's popular public event series, Appetite for Life, continues on Tuesday, March 10 with a free presentation by Patrick Stover, Ph.D., on Keeping a Hungry World Healthy: Our Changing Food...
Series to help laypeople understand science
Saturday, February 14, 2015 • The following has been reprinted from Charlotte Observer, an article by Lisa Thornton. If Dr. Natalia Surzenko told you that choline produces increased hippocampal neurogenesis in Mus musculus, you probably wouldn’t understand. But if she said a nutrient called choline, naturally found in foods such as egg yolks, salmon and cocoa powder has been shown to regenerate brain cells responsible for increased memory in mice, that would be different. At the UNC Nutrition Research Institute in Kannapolis, where Surzenko, a neurobiologist, has her lab, a new series called “Appetite for Life” is intended to create clearer dialogue between researchers and laypeople about discoveries changing the way experts view nutrition.
Diet and Cancer Prevention
Dr. Stephen Hursting, Ph.D., M.P.H.
Choline: An Essential Nutrient
Makes Babies Smarter, Keeps Memory Keen and Prevents Disease, Yet Most Americans Are Missing Out
Choline was discovered in 1862, but scientists did not fully understand its importance—or what foods contained it—for another 136 years. They thought we could make our own choline, much like we make Vitamin D from sunlight and cholesterol, but only women who still produce estrogen can make enough choline—and only if they have the right genes. Forty-five percent of child-bearing women have a genetic variation called a SNP (pronounced “snip”) that prevents them from turning estrogen into choline.
Diet and Extension of Lifespan
Life expectancy keeps growing in developed countries, approaching 90 years on average in some. There is a forecast that more than 50 percent of girls born in the U.S. after 2010 will live to become 100 years or even older, and that the first person to live up to 150 years has already been born.