Microbiome and Nutrition
The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.
Publications
Microbiome and Nutrition Publications
2020
Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K
2019
Association of dietary patterns with the gut microbiota in older, community-dwelling men. Meyer K
2018
Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative. Meyer K
Human microbiota, blood group antigens, and disease. Sumner S
2017
Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease. Zeisel S
2016
Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk. Meyer K
Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S
Related News
Effect of egg ingestion on trimethylamine-N-oxide production in humans: a randomized, controlled, dose-response study
Effect of egg ingestion on trimethylamine-N-oxide production in humans: a randomized, controlled, dose-response study.
Miller CA, Corbin KD, da Costa KA, Zhang S, Zhao X, Galanko JA, Blevins T, Bennett BJ, O’Connor A, Zeisel SH.
Am J Clin Nutr. 2014 Sep;100(3):778-86. doi: 10.3945/ajcn.114.087692. Epub 2014 Jun 18.
PMID: 24944063
A small amount of dietary carbohydrate can promote the HFD-induced insulin resistance to a maximal level
A small amount of dietary carbohydrate can promote the HFD-induced insulin resistance to a maximal level.
Mei S, Yang X, Guo H, Gu H, Zha L, Cai J, Li X, Liu Z, Bennett BJ, He L, Cao W.
PLoS One. 2014 Jul 23;9(7):e100875. doi: 10.1371/journal.pone.0100875. eCollection 2014.
PMID: 25055153
Genetic network identifies novel pathways contributing to atherosclerosis susceptibility in the innominate artery
Genetic network identifies novel pathways contributing to atherosclerosis susceptibility in the innominate artery.
Albright J, Quizon PM, Lusis AJ, Bennett BJ.
BMC Med Genomics. 2014 Aug 12;7:51. doi: 10.1186/1755-8794-7-51.
PMID: 25115202
Responsiveness of cardiometabolic-related microbiota to diet is influenced by host genetics
Responsiveness of cardiometabolic-related microbiota to diet is influenced by host genetics.
O’Connor A, Quizon PM, Albright JE, Lin FT, Bennett BJ.
Mamm Genome. 2014 Aug 27. [Epub ahead of print]
PMID: 25159725
Dietary intake, nutrition, and fetal alcohol spectrum disorders in the Western Cape Province of South Africa
May, PA, Hamrick, KJ, Corbin, KD, Hasken, JM, Marais, AS, Brooke, LE, Blankenship, J, Hoyme, HE, Gossage, JP. (2014) Dietary intake, nutrition and fetal alcohol spectrum disorders in the Western Cape Province of South Africa.
October 2014
SoundBites is the NRI’s monthly e-newsletter. This month features Folami Ideraabdullah’s environmental lecture held at Catawba College and Dr. Zeisel’s input on a new research publication about gut microbes.