Microbiome and Nutrition
The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.
Publications
Microbiome and Nutrition Publications
2020
Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K
2019
Association of dietary patterns with the gut microbiota in older, community-dwelling men. Meyer K
2018
Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative. Meyer K
Human microbiota, blood group antigens, and disease. Sumner S
2017
Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease. Zeisel S
2016
Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk. Meyer K
Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S
Related News
Gut Microbes Can Determine Your Weight
From the desk of: Steve Zeisel, M.D., Ph.D. Gut microbes have been making a lot of news lately. As the name implies, these bacteria reside in the intestine and fulfill a variety of functions essential to our health, specifically ensuring that we digest foods properly....
Alcohol Use, Working Conditions, Job Benefits, and the Legacy of the "Dop" System
Gossage, JP, Snell, CL, Parry, CDH, Marais, AS, Barnard, R, Vries, M, Blankenship, J, Seedat, S, Hasken, JM, May, PA. Alcohol Use, Working Conditions, Job Benefits, and the Legacy of the “Dop” System. In. J. Environ. Res. Public Health 2014, 11, 7406-7424.
Callosal Thickness Reductions relate to Facial Dysmorphology in Fetal Alcohol Spectrum Disorders
Yang, Y, Phillips, OR, Kan, E, Sulik, KK, Mattson, SN, Riley, EP, Jones, KL, Adnams, CM, May, PA, O’Connor, MJ, Narr, KL, Sowell, ER. Callosal Thickness Reductions relate to Facial Dysmorphology in Fetal Alcohol Spectrum Disorders. Alcohol Clin Exp Res. 2012 May; 36(5): 798-806.
Case Management Reduces Drinking During Pregnancy among High Risk Women
May, PA, Marais, AS, Gossage, JP, Barnard, R, Joubert, B, Cloete, M,Hendricks, N, Roux, S, Blom, A, Steenekamp, J, Alexander, T, Andreas, R, Human, S, Snell, C, Seedat, S, Parry, CC, Kalberg WO, Buckey D, Blankenship, J. Case Management Reduces Drinking During Pregnancy among High Risk Women. Int J Alcohol Drug Res. 2013 May 1; 2(3): 61-70.
Executive Function Predicts Adaptive Behavior in Children with Histories of Heavy Prenatal Alcohol Exposure and Attention Deficit/Hyperactivity Disorder
Ware, AL, Crocker, N, O’Brien, JW, Deweese, BN, Roesch, SC, Coles, CD, Kable, JA, May, PA, Kalberg, WO, Sowell, ER, Jones, KL, Riley, EP, Mattson, SN. Executive Function Predicts Adaptive Behavior in Children with Histories of Heavy Prenatal Alcohol Exposure and Attention Deficit/Hyperactivity Disorder. Alcohol Clin Exp Res. 2012 August; 36(8): 1431-1441.
Further Development of a Neurobehavioral Profile of Fetal Alcohol Spectrum Disorders
Mattson, SN, Roesch, SC, Glass, L, Deweese, BN, Coles, CD, Kable, JA, May, PA, Kalberg, WO, Sowell, ER, Adnams, CM, Jones, KL, Riley, EP. Further Development of a Neurobehavioral Profile of Fetal Alcohol Spectrum Disorders. Alcohol Clin Exp Res. 2013 March; 37(3): 517-528.