Microbiome and Nutrition
The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.
Publications
Microbiome and Nutrition Publications
2020
Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K
2019
Association of dietary patterns with the gut microbiota in older, community-dwelling men. Meyer K
2018
Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative. Meyer K
Human microbiota, blood group antigens, and disease. Sumner S
2017
Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease. Zeisel S
2016
Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk. Meyer K
Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S
Related News
Maternal Factors Predicting Cognitive and Behavioral Characteristics of Children with Fetal Alcohol Spectrum Disorders
May, PA, Tabachnick, BG, Gossage, JP, Kalberg, WO, Marais, AS, Robinson, LK, Manning, MA, Blankenship, J, Buckley, D, Hoyme, HE, Adnams, CM. Maternal Factors Predicting Cognitive and Behavioral Characteristics of Children with Fetal Alcohol Spectrum Disorders. J Dev Behav Pediatr. 2013 June; 34 (5): 314-325.
Prenatal Alcohol Exposure, ADHD, and Sluggish Cognitive Tempo
Graham, DM, Crocker, N, Deweese, BN, Roesch, SC, Coles, CD, Kable, JA, May, PA, Kalberg, WO, Sowell, ER, Jones, KL, Riley, EP, Mattson, SN. Prenatal Alcohol Exposure, ADHD, and Sluggish Cognitive Tempo. Alcohol Clin Exp Res. 2013 January; 37 (Suppl 1): E338-E346.
The Effects of Prenatal Alcohol Exposure and Attention-Deficit/Hyperactivity Disorder on Psychopathology and Behavior
Ware, AL, O’Brien, J W, Crocker, N, Deweese, BN, Roesch, SC, Coles, CD, Kable, JA, May, PH, Kalber, WO, Soweel, ER, Jones, KL, Riley, EP, Mattson, SN. The Effects of Prenatal Alcohol Exposure and Attention-Deficit/Hyperactivity Disorder on Psychopathology and Behavior. Alchol Clin Exp Res. 2013 March; 37(3): 507-516. doi:10.1111/j.1530-02777.2012.01953x.
Approaching the Prevalence of the Full Spectrum of Fetal Alcohol Spectrum Disorders in a South African Population-Based Study
May, PA, Blankenship, J, Marais, A, Gossage, JP, Kalberg, WO, Barnard, R, Vries, M, Robinson, LK, Adnams, CM, Buckley, D, Manning, M, Jones, KL, Parry, C, Hoyme, HE, Seedat, S. Approaching the Prevalence of the Full Spectrum of Fetal Alcohol Spectrum Disorders in a South African Population-Based Study. Alcohol Clin Exp Res. 2013 May; 37(5): 8180830. doi:10.1111/acer.12033.
Regional Brain Volume Reductions Relate to Facial Dysmorphology and Neurocognitive Function in Fetal Alcohol Spectrum Disorders
Roussotte, FF, Sulik, KK, Mattson, SN, Riley, EP, Jones, KL, Adnams, CM, May, PA, O’Connor, MJ, Narr, KL, Sowell, ER. Regional Brain Volume Reductions Relate to Facial Dysmorphology and Neurocognitive Function in Fetal Alchohol Spectrum Disorders. Hum Brain Mapp. 2012 April; 33 (4): . doi:10.1002/hbm.21260
Stephen Hursting, Ph.D., M.P.H.
Stephen Hursting, Ph.D., M.P.H. is interested in diet-gene interactions relevant to cancer prevention, particularly the molecular and hormonal mechanisms underlying energy balance-cancer associations.