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Microbiome and Nutrition

The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.

Publications

 

Microbiome and Nutrition Publications

2020

Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K

2019

Association of dietary patterns with the gut microbiota in older, community-dwelling men.  Meyer K

The impact of early-life sub-therapeutic antibiotic treatment (STAT) on excessive weight is robust despite transfer of intestinal microbes.  Sumner S

Protein Intake at Twice the RDA in Older Men Increases Circulatory Concentrations of the Microbiome Metabolite Trimethylamine-N-Oxide (TMAO).  Zeisel S

2018

Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative.  Meyer K

Human microbiota, blood group antigens, and disease.  Sumner S

2017

Dietary Choline and Betaine and Risk of CVD: A Systematic Review and Meta-Analysis of Prospective Studies.  Meyer K

A Microbiomic Analysis in African Americans with Colonic Lesions Reveals Streptococcus sp.VT162 as a Marker of Neoplastic Transformation.  Sumner S

Metabolic profiling of a chronic kidney disease cohort reveals metabolic phenotype more likely to benefit from a probiotic.  Sumner S

Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease.  Zeisel S

2016

Microbiota-Dependent Metabolite Trimethylamine N-Oxide and Coronary Artery Calcium in the Coronary Artery Risk Development in Young Adults Study (CARDIA).  Meyer K

Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk.  Meyer K

Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S

Related News

Effects of Calorie Restriction and Diet-Induced Obesity on Murine Colon Carcinogenesis, Growth and Inflammatory Factors, and MicroRNA Expression

December 30, 2014

Effects of calorie restriction and diet-induced obesity on murine colon carcinogenesis, growth and inflammatory factors, and microRNA expression.
Olivo-Marston SE, Hursting SD, Perkins SN, Schetter A, Khan M, Croce C, Harris CC, Lavigne J.
PLoS One. 2014 Apr 14;9(4):e94765. doi: 10.1371/journal.pone.0094765. eCollection 2014.
PMID: 24732966

Calorie restriction decreases murine and human pancreatic tumor cell growth, nuclear factor-κB activation, and inflammation-related gene expression in an insulin-like growth factor-1-dependent manner

December 30, 2014

Calorie restriction decreases murine and human pancreatic tumor cell growth, nuclear factor-κB activation, and inflammation-related gene expression in an insulin-like growth factor-1-dependent manner.
Harvey AE, Lashinger LM, Hays D, Harrison LM, Lewis K, Fischer SM, Hursting SD.
PLoS One. 2014 May 7;9(5):e94151. doi: 10.1371/journal.pone.0094151. eCollection 2014.
PMID: 24804677