Microbiome and Nutrition
The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.
Publications
Microbiome and Nutrition Publications
2020
Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K
2019
Association of dietary patterns with the gut microbiota in older, community-dwelling men. Meyer K
2018
Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative. Meyer K
Human microbiota, blood group antigens, and disease. Sumner S
2017
Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease. Zeisel S
2016
Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk. Meyer K
Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S
Related News
Phosphatidylcholine Supplementation in Pregnant Women Consuming Moderate-Choline Diets Does Not Enhance Infant Cognitive Function
Cheatham, C.L., Goldman, B.D., Fischer, L.M., da Costa, K-A, Reznick, S., Zeisel, S.H. (2012) Phosphatidylcholine supplementation in pregnant women consuming moderate choline diets does not enhance infant cognitive function: a randomized double-blind placebo-controlled trial. American Journal of Clinical Nutrition. doi: 10.3945/ajcn.112.037184.
Choline Metabolism Provides Novel Insights into Non-Alcoholic Fatty Liver Disease and its Progression
Corbin, KD, Zeisel, SH. (2012) Choline Metabolism Provides Novel Insights into Non-alcoholic Fatty Liver Disease and its Progression. Curr Opin Gastroenterol. 28:159-165. PMID:22134222
Protein Kinase Cα Phosphorylates a Novel Argininosuccinate Synthase Site at Serine 328 during Calcium-dependent Stimulation of Endothelial Nitric-oxide Synthase in Vascular Endothelial Cells
Haines, RJ, Corbin, KD, Pendleton, LC, Eichler, DE. (2012) PKCα Phosphorylates a Novel Argininosuccinate Synthase Site at S328 During Calcium-Dependent Stimulation of eNOS in Vascular Endothelial Cells. J Biol Chem. 287: 26168–26176. PMID:22696221
Insulin transcriptionally regulates argininosuccinate synthase to maintain vascular endothelial function
Haines, RJ, Corbin, KD, Pendleton, LC, Meininger, CJ Eichler, DE. (2012) Insulin transcriptionally regulates argininosuccinate synthase to maintain vascular endothelial function. Biochem Biophys Res Commun. 421:9-14.
Choline Dehydrogenase Polymorphism RS12676 is a Functional Variation and is Associated with Changes in Human Sperm Cell Function
Johnson, A.R., Lao, S., Wang, T., Galanko, J.A., Zeisel, S.H. (2012) Choline dehydrogenase polymorphism rs12676 is a functional variation and is associated with changes in human sperm cell function. PLoS ONE. 7(4): e36047. PMID: 22558321.
Perinatal Epigenetic Determinants of Cognitive and Metabolic Disorders
Lupu DS and Niculescu MD (2012) Perinatal Epigenetic Determinants of Cognitive and Metabolic Disorders. Aging and Disease 3